Evidence map›Paper›PMID 36170660›Full record

ReviewAnnual review of physiology2023

Infectious and Inflammatory Pathways to Cough.

Kubra F Naqvi, Stuart B Mazzone, Michael U Shiloh

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Annual review of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07524712 (Preliminary Study on the Associated Mechanisms Between Surgical Instruments and Postoperative Cough), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07524712 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Preliminary Study on the Associated Mechanisms Between Surgical Instruments and Postoperative Cough

TypeinterventionalSponsorTongji HospitalRan2026 to 2028Enrolled248ConditionsPostoperative Cough, Cough Hypersensitivity SyndromeArmsEnergy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Sulfolipid-1 fromJournal of neurophysiology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Kubra F NaqviDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; email: Michael.shiloh@utsouthwestern.edu.
Stuart B MazzoneDepartment of Anatomy and Physiology, University of Melbourne, Victoria, Australia.
Michael U ShilohDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; email: Michael.shiloh@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USUniversity of Melbourne · AU

Funding

Transmission Aerobiology of M. tuberculosis: Genes and Metabolic Pathways That Sustain Mtb Across an Evolutionary BottleneckP01AI159402 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI NATHAN, CARL FRANCIS, RHEE, KYU Y · 2021 to 2025
$15.8M
MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Mechanisms of cough in Mycobacterium tuberculosis transmissionR01AI158688 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SHILOH, MICHAEL · 2021 to 2025
$3.6M
NIAID NIH HHS P01 AI159402NIAID NIH HHS R01 AI158688NIAID NIH HHS T32 AI007520
6 · The paper itself

Abstract

Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens to facilitate disease transmission. Microbial components or infection-induced inflammatory mediators can directly interact with sensory nerve receptors to induce a cough response. Analysis of cough-generated aerosols and transmission studies have further demonstrated how infectious disease is spread through coughing. This review summarizes the neurophysiology of cough, cough induction by respiratory pathogens and inflammation, and cough-mediated disease transmission.

Indexed as

Communicable DiseasesCoughHumansRespiratory SystemSensory Receptor CellsVagus Nervecoughdisease transmissionrespiratory tract infectionssensory neurons

Identifiers

PMID36170660
PMCPMC9918720
OpenAlexW4297518727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.