Evidence map›Paper›PMID 36170654›Full record

Trial reportAnnals of the American Thoracic Society2023

Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.

Anne E Dixon, Loretta G Que, Ravi Kalhan, Mark T Dransfield, Linda Rogers, Lynn B Gerald, Monica Kraft, Jerry A Krishnan, Olivia Johnson, Heather Hazucha and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of the American Thoracic Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Anne E DixonDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Loretta G QueDepartment of Medicine, Duke University Health System, Durham, North Carolina.
Ravi KalhanDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0003-2443-0876
Mark T DransfieldDepartment of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Linda RogersMount Sinai-National Jewish Health Respiratory Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Lynn B GeraldHealth Promotion Sciences and.
Monica KraftDepartment of Medicine, College of Medicine, Mel and Enid Zuckerman College of Public Health & Asthma and Airway Disease Research Center, University of Arizona, Tucson, Arizona.
Jerry A KrishnanBreathe Chicago Center, University of Illinois Chicago, Chicago, Illinois; and.ORCID 0000-0001-5525-4778
Olivia JohnsonDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Heather HazuchaBloomberg School of Public Health and.
Gem RoyBloomberg School of Public Health and.
Janet T HolbrookBloomberg School of Public Health and.
Robert A WiseBloomberg School of Public Health and.ORCID 0000-0002-8353-2349
Johns Hopkins University · USUniversity of Vermont · USDuke University Health System · USHealth Promotion Services · USMount Sinai Health System · USNorthwestern University · USUniversity of Alabama at Birmingham · USUniversity of Arizona · USUniversity of Illinois Chicago · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Trial of Roflumilast in Asthma Management (TRIM)R34HL135361 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E · 2017 to 2019
$597k
UAB Mentoring Program in COPD Patient Oriented ResearchK24HL140108 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2018 to 2022
$439k
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS K24 HL140108NHLBI NIH HHS R34 HL135361NIEHS NIH HHS P30 ES006694NIH HHS R34HL135361
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AsthmaPulmonary Disease, Chronic ObstructiveAminopyridinesBenzamidesCyclopropanesDouble-Blind MethodHumansObesityAminopyridinesBenzamidesCyclopropanesRoflumilastasthma controlasthma exacerbationquality of lifeweight loss

Identifiers

PMID36170654
PMCPMC9989863
OpenAlexW4297519303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.