Evidence map›Paper›PMID 36169799›Full record

ArticlePain and therapy2022

Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study.

Ryota Yanaizumi, Yusuke Nagamine, Shinsuke Harada, Tomoko Kuramochi, Shuhei Ota, Yoichiro Abe, Masayuki Nakagawa, Kenya Kamijima, Maya Hayashi, Toshiharu Tazawa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Ryota YanaizumiDepartment of Anesthesiology, Yokohama City University Medical Center, Yokohama, Japan.
Yusuke NagamineDepartment of Anesthesiology and Critical Care Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan. ynagamin@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0002-0443-5007
Shinsuke HaradaYu Home Care Clinic Asahi, Yokohama, Japan.
Tomoko KuramochiDepartment of Palliative Care, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Shuhei OtaDepartment of Palliative Medicine, Kanagawa Cancer Center, Kanagawa, Japan.
Yoichiro AbeDepartment of Pain Clinic, NTT Medical Center Tokyo, Tokyo, Japan.
Masayuki NakagawaDepartment of Pain Clinic, NTT Medical Center Tokyo, Tokyo, Japan.
Kenya KamijimaDepartment of Pain Clinic, NTT Medical Center Tokyo, Tokyo, Japan.
Maya HayashiDepartment of Pain Clinic, NTT Medical Center Tokyo, Tokyo, Japan.
Toshiharu TazawaDepartment of Anesthesiology, Saint Marianna University School of Medicine, Kawasaki, Japan.
Kenichi OgawaKugenuma Palliative Care Internal Medicine, Fujisawa, Japan.
Takahisa GotoDepartment of Anesthesiology and Critical Care Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
NTT Medical Center · JPYokohama City University Hospital · JPKanagawa Prefectural Hospital Organization · JPMiwa Internal Medicine Clinic · JPSt. Marianna University School of Medicine · JPYokohama City University Medical Center · JPYokohama Municipal Citizen's Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCeliac plexus block is effective for treating intractable cancer pain and has been the focus of many studies. Several guiding techniques such as fluoroscopy, computed tomography, and endoscopy have been devised, and the target of the block has varied in previous studies as both the celiac plexus and splanchnic nerve, which is the main origin of the celiac plexus, have been targeted. At our affiliated institution, fluoroscopy-guided splanchnic nerve block with a single needle via transintervertebral disc approach is the first choice. However, there have been few reports on the use of this technique. This study investigated the efficacy and safety of this technique.

methodsThis multicenter retrospective observational study reviewed the medical records of patients who underwent neurolytic splanchnic nerve block (NSNB) via transintervertebral disc approach for intractable cancer pain at five tertiary hospitals in Japan from April 2005 to October 2020. The primary outcome was the clinical success ratio of NSNB, and the secondary outcome was the incidence ratio of NSNB-related adverse events.

resultsIn total, 103 patients were included in the analysis. Of these, 77 patients met the definition of clinical success, with a ratio of 74.8%. The incidence ratio of NSNB-related adverse events was 40.8% (hypotension, 21.4%; alcohol intoxication, 13.6%; diarrhea, 11.7%; and vascular puncture, 3.9%; duplicates were present). All adverse events improved with observation and symptomatic treatment only. No patient had infection or serious adverse events such as organ or nerve damage.

conclusionsThe clinical success ratio of this technique was 74.8%. Although the incidence of adverse events was 40.8%, all events were mild and no serious adverse events were observed. The findings demonstrate the efficacy and safety of our NSNB in patients with intractable cancer pain.

Indexed as

Cancer painFluoroscopically guidedNeurolytic splanchnic nerve blockRetrocrural spaceSingle needleTransintervertebral disc approach technique

Identifiers

PMID36169799
PMCPMC9633912
OpenAlexW4297488789

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.