ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023
Optimal MoCA cutoffs for detecting biologically-defined patients with MCI and early dementia.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-analysis of Montreal cognitive assessment diagnostic accuracy in amnestic mild cognitive impairment.Frontiers in psychology · 2024Pooled it
- Auditory and executive determinants of phonetic processing and lexical acquisition in older adults with mild hearing impairment and cognitive decline.GeroScience · 2026Article
- Quantifying the added value of foot-controlled force variables in predicting mild cognitive impairment.Scientific reports · 2026Article
- Multimodal neuroimaging approach for cognitive impairment in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- The Montreal Cognitive Assessment at the Framingham Heart Study: A Re-Examination of the Norms.Brain and behavior · 2026Article
- Exploring curiosity, interest, and surprise: normative ratings of a magic trick video dataset in Italy.Scientific data · 2026Article
- Baseline cognitive status and adherence are associated with cognitive change following language learning in older adults: an exploratory study.Frontiers in aging · 2026Article
- White matter microstructure disruption associated with PET and cognitive impairment in Alzheimer's disease.PloS one · 2026Article
- Cognitive Impairment: A Novel Risk Factor for Rapid Kidney Function Decline and Incident CKD in Middle-Aged Adults.Kidney360 · 2025Article
- Exploring apathy components and their relationship in cognitive decline: insights from a network cross-sectional study.BMC psychology · 2025Article
- Resting-State EEG Power Spectral Density Analysis Between Healthy and Cognitively Impaired Subjects.Brain sciences · 2025Article
- No matter how big it is, but how you use it: the importance of demographic adjustment in clinical neuropsychology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Prevalence of Mild and Severe Cognitive Impairment in World Trade Center Exposed Fire Department of the City of New York (FDNY) and General Emergency Responders.American journal of industrial medicine · 2025Article
- Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort.Biomedicines · 2025Article
- Deficits in reaching movements under visual interference as a novel diagnostic marker for mild cognitive impairment.Scientific reports · 2025Article
- Normative data of the Spanish version of the Montreal Cognitive Assessment (MoCA) in older individuals from Peru.Dementia & neuropsychologia · 2025Article
- Prevalence of Mild and Severe Cognitive Impairment in World Trade Center Exposed Fire Department of the City of New York (FDNY) and General Emergency Responders.medRxiv : the preprint server for health sciences · 2024Article
- Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Cardiac sympathetic denervation and anxiety in Parkinson disease.Parkinsonism & related disorders · 2024Article
- Ocular biomarkers of cognitive decline based on deep-learning retinal vessel segmentation.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this phase II psychometric study on the Montreal cognitive assessment (MoCA), we tested the clinicometric properties of Italian norms for patients with mild cognitive impairment (PwMCI) and early dementia (PwD) and provided optimal cutoffs for diagnostic purposes.
methodsRetrospective data collection was performed for consecutive patients with clinically and biologically defined MCI and early dementia. Forty-five patients (24 PwMCI and 21 PwD) and 25 healthy controls were included. Raw MoCA scores were adjusted according to the conventional 1-point correction (Nasreddine) and Italian norms (Conti, Santangelo, Aiello). The diagnostic properties of the original cutoff (< 26) and normative cutoffs, namely, the upper limits (uLs) of equivalent scores (ES) 1, 2, and 3, were evaluated. ROC curve analysis was performed to obtain optimal cutoffs.
resultsThe original cutoff demonstrated high sensitivity (0.93 [95% CI 0.84-0.98]) but low specificity (0.44 [0.32-0.56]) in discriminating between patients and controls. Nominal normative cutoffs (ES0 uLs) showed excellent specificity (SP range = 0.96-1.00 [0.88-1.00]) but poor sensitivity (SE range = 0.09-0.24 [0.04-0.36]). The optimal cutoff for Nasreddine's method was 23.50 (SE = 0.82 [0.71-0.90]; SP = 0.72 [0.60-0.82]). Optimal cutoffs were 20.97, 22.85, and 22.29 (SE range = 0.69-0.73 [0.57-0.83], SP range = 0.88-0.92 [0.77-0.97]) for Conti's, Santangelo's, and Aiello's methods, respectively.
conclusionUsing the 1-point correction, combined with a cutoff of 23.50, might be useful in ambulatory settings with a large turnout. Our optimal cutoffs can offset the poor sensitivity of Italian cutoffs.
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