Evidence map›Paper›PMID 36169748›Full record

ArticleDigestive diseases and sciences2023

COVID-19 Pandemic Had Minimal Impact on Colonoscopy Completion After Colorectal Cancer Red Flag Sign or Symptoms in US Veterans.

Joshua Demb, Lin Liu, Ranier Bustamante, Jason A Dominitz, Ashley Earles, Shailja C Shah, Andrew J Gawron, Maria Elena Martinez, Samir Gupta

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04389957 (Improving Colonoscopy Quality for Colorectal Cancer Screening in the National VA Healthcare System), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04389957 completednot on this map

Improving Colonoscopy Quality for Colorectal Cancer Screening in the National VA Healthcare System

TypeobservationalSponsorVA Office of Research and DevelopmentRan2020 to 2024Enrolled445ConditionsColorectal NeoplasmsArmsVeterans Affairs Endoscopy Quality Improvement Program (VA-EQuIP)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Joshua DembJennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA. jdemb@health.ucsd.edu.ORCID http://orcid.org/0000-0002-3338-1730
Lin LiuJennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.
Ranier BustamanteJennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.
Jason A DominitzNational Gastroenterology and Hepatology Program, Veterans Health Administration, Washington, DC, USA.
Ashley EarlesJennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.
Shailja C ShahJennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.
Andrew J GawronVA Salt Lake City Health Care System, Salt Lake City, UT, USA.
Maria Elena MartinezHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.
Samir GuptaJennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.
University of California San Diego · USVA San Diego Healthcare System · USUC San Diego Health System · USUnited States Department of Veterans Affairs · USUniversity of Utah · US

Funding

Post-polypectomy Surveillance for Reducing Colon Cancer Incidence and MortalityR37CA222866 · NCI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GUPTA, SAMIR · 2018 to 2023
$3.3M
Colonoscopy in young onset colorectal cancerF32CA239360 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEMB, JOSHUA BRIAN · 2019 to 2022
$227k
Optimization of Helicobacter pylori-related Disease Outcomes in VeteransIK2CX002027 · VA · VETERANS HEALTH ADMINISTRATION · PI SHAILJA C SHAH · 2020 to 2026
–
CSRD VA IK2 CX002027HSRD VA I01 HX001574NCI NIH HHS F32 CA239360NCI NIH HHS R37 CA222866
6 · The paper itself

Abstract

backgroundDelays in colonoscopy work-up for red flag signs or symptoms of colorectal cancer (CRC) during the COVID-19 pandemic are not well characterized.

aimsTo examine colonoscopy uptake and time to colonoscopy after red flag diagnosis, before and during the COVID-19 pandemic.

methodsCohort study of adults ages 50-75 with iron deficiency anemia (IDA), hematochezia, or abnormal stool blood test receiving Veterans Health Administration (VHA) care from April 2019 to December 2020. Index date was first red flag diagnosis date, categorized into "pre" (April-December 2019) and "intra" (April-December 2020) policy implementation prioritizing diagnostic procedures, allowing for a 3-month "washout" (January-March 2020) period. Outcomes were colonoscopy completion and time to colonoscopy pre- vs. intra-COVID-19, examined using multivariable Cox models with hazard ratios (aHRs) and 95% confidence intervals (CIs).

resultsThere were 52,539 adults with red flag signs or symptoms (pre-COVID: 25,154; washout: 7527; intra-COVID: 19,858). Proportion completing colonoscopy was similar pre- vs. intra-COVID-19 (27.0% vs. 26.5%; p = 0.24). Median time to colonoscopy among colonoscopy completers was similar for pre- vs. intra-COVID-19 (46 vs. 42 days), but longer for individuals with IDA (60 vs. 49 days). There was no association between time period and colonoscopy completion (aHR: 0.99, 95% CI 0.95-1.03).

conclusionsColonoscopy work-up of CRC red flag signs and symptoms was not delayed within VHA during the COVID-19 pandemic, possibly due to VHA policies supporting prioritization and completion. Further work is needed to understand how COVID-19 policies on screening and surveillance impact CRC-related outcomes, and how to optimize colonoscopy completion after a red flag diagnosis.

Indexed as

Colorectal NeoplasmsCOVID-19VeteransAdultAgedCohort StudiesColonoscopyEarly Detection of CancerHumansIronMiddle AgedPandemicsIronColonoscopyColorectal cancerCOVID-19DiagnosisSymptoms

Identifiers

PMID36169748
PMCPMC9516530
OpenAlexW4297461692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.