Evidence map›Paper›PMID 36169731›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

mRNA-1273 SARS-CoV-2 vaccine safety and COVID-19 risk perception in recently transplanted allogeneic hematopoietic stem cell transplant recipients.

Nil Albiol, Olga Aso, Lucía Gómez-Pérez, Mercè Triquell, Nerea Roch, Elisabeth Lázaro, Albert Esquirol, Iria González, Joaquín López-Contreras, Jorge Sierra and 2 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Vaccination of Adults With Cancer: ASCO Guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Nil AlbiolHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain. nilalbiol@iconcologia.net.ORCID http://orcid.org/0000-0003-2942-1362
Olga AsoHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Lucía Gómez-PérezHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Mercè TriquellHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Nerea RochInfectious Diseases Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Elisabeth LázaroHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Albert EsquirolHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Iria GonzálezHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Joaquín López-ContrerasAutonomous University of Barcelona, Barcelona, Spain.
Jorge SierraHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Rodrigo MartinoHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Irene García-CadenasHematology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain. igarciaca@santpau.cat.ORCID http://orcid.org/0000-0002-2994-9055
Hospital de Sant Pau · ESUniversitat Autònoma de Barcelona · ES

Funding

Fundació la Marató de TV3 517C/20190318/1330Instituto de Salud Carlos III AGAUR 2017 SGR 865Instituto de Salud Carlos III FIS PI17/01246Instituto de Salud Carlos III Tercel RD16/0011/0028
6 · The paper itself

Abstract

purposeThis study aims to describe the incidence and severity of adverse events (AEs) following the mRNA-1273 SARS-CoV-2 vaccine and explore the risk perception of COVID-19 in allogeneic hematopoietic stem cell transplant (HCT) recipients.

methodsWe performed a single-center prospective study including recently transplanted (< 2 years post-infusion) allogeneic HCT recipients. AEs were assessed through phone calls and graded from 0 to 4, while COVID-19 risk perception was measured using the Brief Illness Perception Questionnaire (BIP-Q5).

resultsFifty-four HCT recipients were evaluated. Incidence and grades of AE (94.4% and 85.2% after the first and second dose, respectively) were similar to those described in the general population. The most common AE was pain at the site of injection. Three patients (5.6%) developed a grade ≥ 3 AE. Vaccine-related cytopenias and graft-versus-host disease flares were not observed. Female sex (OR 3.94, 95% CI 1.14-13.58, p = 0.03) and time since HCT (per month since HCT: OR 1.09, 95% CI 1.01-1.18, p = 0.04) were associated with the occurrence of any AE. The patients' risk perception level of COVID-19 decreased over time (p < 0.05).

conclusionOur study confirms that the mRNA-1273 SARS-CoV-2 vaccine is safe in recent HCT recipients and suggests that the perceived risk of COVID-19 decreases over time.

Indexed as

2019-nCoV Vaccine mRNA-1273COVID-19Hematopoietic Stem Cell TransplantationFemaleHealth Knowledge, Attitudes, PracticeHumansProspective StudiesSARS-CoV-2Surveys and QuestionnairesTransplantation, Homologous2019-nCoV Vaccine mRNA-1273Adverse eventsAllogeneic stem cell transplantationCOVID-19mRNA-1273Risk perception

Identifiers

PMID36169731
PMCPMC9517991
OpenAlexW4297461619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.