SynthesiseLife2022
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis.
Synthesis in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Cortical Gradients Support Mental Time Travel into the Past and Future: Evidence from Activation Likelihood Estimation Meta-analysis.Neuropsychology review · 2026Pooled it
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- Precision fMRI reveals densely interdigitated network patches with conserved motifs in the lateral prefrontal cortex.Neuron · 2026Article
- Reversed functional gradient in primate prefrontal cortex: Posterior dominance and frontopolar task-related deactivation.Science advances · 2026Article
- Individualized parcellation reveals functional boundaries in human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Frontal cortex organization supporting audiovisual processing during naturalistic viewing.Nature communications · 2026Article
- Protracted Functional and Structural Reorganization of Human Prefrontal Cortex Supports Lateralized Category Geometries.bioRxiv : the preprint server for biology · 2026Article
- Differential representations of spatial environments in mPFC and hippocampus underpinning flexible navigation.NeuroImage · 2026Article
- Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting.bioRxiv : the preprint server for biology · 2025Article
- Encoding of visual stimuli and behavioral goals in distinct anatomical areas of monkey ventrolateral prefrontal cortex.PLoS biology · 2025Article
- The Dimensionality of Neural Coding for Cognitive Control Is Gradually Transformed within the Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Striato-cortical connectivity patterns predict clinical profiles in Huntington's disease.NeuroImage. Clinical · 2025Article
- Cognitive Control.Annual review of psychology · 2025Review
- On the construction of artificial general intelligence based on the correspondence between goals and means.Frontiers in artificial intelligence · 2025Article
- Investigating Cerebello-Frontal Circuits Associated with Emotional Prosody: A Double-Blind tDCS and fNIRS study.Cerebellum (London, England) · 2024Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.Current biology : CB · 2024Article
- Graded functional organization in the left inferior frontal gyrus: evidence from task-free and task-based functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.bioRxiv : the preprint server for biology · 2023Article
- A new open, high-resolution, multishell, diffusion-weighted imaging dataset of the living squirrel monkey.Scientific data · 2023Article
- Cingulo-Opercular Subnetworks Motivate Frontoparietal Subnetworks during Distinct Cognitive Control Demands.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lateral prefrontal cortex (LPFC) of humans enables flexible goal-directed behavior. However, its functional organization remains actively debated after decades of research. Moreover, recent efforts aiming to map the LPFC through meta-analysis are limited, either in scope or in the inferred specificity of structure-function associations. These limitations are in part due to the limited expressiveness of commonly-used data analysis tools, which restricts the breadth and complexity of questions that can be expressed in a meta-analysis. Here, we adopt NeuroLang, a novel approach to more expressive meta-analysis based on probabilistic first-order logic programming, to infer the organizing principles of the LPFC from 14,371 neuroimaging studies. Our findings reveal a rostrocaudal and a dorsoventral gradient, respectively explaining the most and second most variance in meta-analytic connectivity across the LPFC. Moreover, we identify a unimodal-to-transmodal spectrum of coactivation patterns along with a concrete-to-abstract axis of structure-function associations extending from caudal to rostral regions of the LPFC. Finally, we infer inter-hemispheric asymmetries along the principal rostrocaudal gradient, identifying hemisphere-specific associations with topics of language, memory, response inhibition, and sensory processing. Overall, this study provides a comprehensive meta-analytic mapping of the LPFC, grounding future hypothesis generation on a quantitative overview of past findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.