Evidence map›Paper›PMID 36169308›Full record

ArticleProceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine2022

Effect of vitrification on mechanical properties of porcine articular cartilage.

Jenny He, Itai Wine, Kezhou Wu, Johnathan Sevick, Leila Laouar, Nadr M Jomha, Lindsey Westover

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jenny HeDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Itai WineDepartment of Civil and Environmental Engineering, University of Alberta, Edmonton, AB, Canada.
Kezhou WuDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Johnathan SevickDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Leila LaouarDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Nadr M JomhaDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Lindsey WestoverDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-1220-3967

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Articular cartilage (AC) injuries do not heal primarily and large lesions progress to degenerative osteoarthritis. Osteochondral allograft transplantation is an effective surgical treatment but is limited by the lack of donor tissue availability. Fresh allografts can be stored hypothermically up to 28-45 days after which the tissue is no longer viable for transplantation. Vitrification is a method of cryopreservation with the potential to extend the storage time of AC. A specific protocol has been demonstrated to preserve high chondrocyte viability; however, its effect on various mechanical properties of the extracellular matrix (ECM) remains unknown and is the focus of this initial study. Porcine AC was subject to a defined vitrification protocol, using fresh and frozen samples as positive and negative controls, respectively;

Indexed as

Cartilage, ArticularVitrificationAnimalsChondrocytesCryopreservationSwinearthritisArticular cartilagemechanical propertiestransplantationvitrification

Identifiers

PMID36169308
PMCPMC9574425

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.