ArticleeLife2022
Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 27 citations in OpenAlex.
- Model-based semantic distance reveals adaptive coordination of distinct cognitive systems in flexible knowledge retrieval.Nature communications · 2026Article
- Functional connectivity gradients depend on cortical sampling position and brain state.bioRxiv : the preprint server for biology · 2026Article
- Blunted modulation of hierarchical brain organization in opioid use disorder.Research square · 2026Article
- The Neural Processes Underpinning Flexible Semantic Retrieval in Visual and Auditory Modalities.Human brain mapping · 2026Article
- Differences of Gradient Connectivity and Ventricle Volumes in Long-Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures.Human brain mapping · 2026Article
- Functional connectome gradient alterations in herpes zoster and postherpetic neuralgia: associations with gene expression profiles.The journal of headache and pain · 2026Article
- Network hierarchy in Alzheimer's and Lewy body spectrum disorders: functional gradients, cognitive phenotypes, and translational gaps.Frontiers in aging neuroscience · 2026Review
- Multivariate Association Between Functional Connectivity Gradients and Cognition in Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Whole-Brain Dimensions of Intrinsic Connectivity Capture Modality-Specific and Heteromodal Language Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls.CNS neuroscience & therapeutics · 2025Article
- Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD.Nature communications · 2025Article
- A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity.Scientific reports · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
- The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks.Frontiers in psychiatry · 2025Article
- Divergent and convergent creativity relate to different aspects of semantic control.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Local Gradients of Functional Connectivity Enable Precise Fingerprinting of Infant Brains During Dynamic Development.bioRxiv : the preprint server for biology · 2024Article
- Opportunities and challenges in connectivity analysis for task-based fMRI comment on "connectivity analyses for task-based fMRI" by Huang S, De Brigard, F., Cabeza, R, and Davis, S.W.Physics of life reviews · 2024Article
- Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community.Neuroinformatics · 2024Review
- Macroscale brain states support the control of semantic cognition.Communications biology · 2024Article
- Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Understanding how thought emerges from the topographical structure of the cerebral cortex is a primary goal of cognitive neuroscience. Recent work has revealed a principal gradient of intrinsic connectivity capturing the separation of sensory-motor cortex from transmodal regions of the default mode network (DMN); this is thought to facilitate memory-guided cognition. However, studies have not explored how this dimension of connectivity changes when conceptual retrieval is controlled to suit the context. We used gradient decomposition of informational connectivity in a semantic association task to establish how the similarity in connectivity across brain regions changes during familiar and more original patterns of retrieval. Multivoxel activation patterns at opposite ends of the principal gradient were more divergent when participants retrieved stronger associations; therefore, when long-term semantic information is sufficient for ongoing cognition, regions supporting heteromodal memory are functionally separated from sensory-motor experience. In contrast, when less related concepts were linked, this dimension of connectivity was reduced in strength as semantic control regions separated from the DMN to generate more flexible and original responses. We also observed fewer dimensions within the neural response towards the apex of the principal gradient when strong associations were retrieved, reflecting less complex or varied neural coding across trials and participants. In this way, the principal gradient explains how semantic cognition is organised in the human cerebral cortex: the separation of DMN from sensory-motor systems is a hallmark of the retrieval of strong conceptual links that are culturally shared.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.