Evidence map›Paper›PMID 36169277›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2022

Expression and Clinical Significance of Spi-B in B-cell Acute Lymphoblastic Leukemia.

Yuzuru Ariga, Shulin Low, Hitomi Hoshino, Tsutomu Nakada, Tomoya O Akama, Akifumi Muramoto, Mana Fukushima, Takahiro Yamauchi, Yusei Ohshima, Motohiro Kobayashi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Expression of Glycoprotein 2 and Its Glycosylation in Human Cowper's Gland.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuzuru ArigaDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Shulin LowDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Hitomi HoshinoDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Tsutomu NakadaDepartment of Instrumental Analysis, Research Center for Advanced Science and Technology, Shinshu University, Matsumoto, Japan.
Tomoya O AkamaDepartment of Pharmacology, Kansai Medical University, Hirakata, Japan.ORCID 0000-0003-4248-6929
Akifumi MuramotoDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Mana FukushimaDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Takahiro YamauchiDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Yusei OhshimaDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.ORCID 0000-0002-4488-0308
Motohiro KobayashiDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.ORCID 0000-0002-7607-0801
University of Fukui · JPKansai Medical University · JPShinshu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spi-B, a member of the E26 transformation-specific (ETS) family of transcription factors, plays an important role in B cell differentiation. Spi-B also functions in development of diffuse large B-cell lymphoma; thus, we hypothesized that it may participate in leukemogenesis of B-cell acute lymphoblastic leukemia (B-ALL). To test this hypothesis, we first generated an anti-Spi-B monoclonal antibody that recognized Spi-B on formalin-fixed, paraffin-embedded tissue sections. This antibody, designated S28-5, selectively stained B cell nuclei at the pre-plasma cell stage (including centrocytes and centroblasts in germinal centers) and nuclei of plasmacytoid dendritic cells, but not fully differentiated plasma cells, T cells, macrophages, or follicular dendritic cells. Employing S28-5, we then performed immunohistochemical staining of bone marrow aspiration biopsy specimens obtained from B-ALL patients (

Indexed as

Burkitt LymphomaLymphoma, Large B-Cell, DiffusePrecursor Cell Lymphoblastic Leukemia-LymphomaB-LymphocytesHumansUric AcidUric Acidaspiration biopsybone marrowimmunohistochemistry

Identifiers

PMID36169277
PMCPMC9660366
OpenAlexW4297459106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.