Evidence map›Paper›PMID 36169248›Full record

ArticleImmunity, inflammation and disease2022

The frequency of CD4+ and CD8+ circulating T stem cell memory in type 1 diabetes.

Pooriya Fazeli, Atefe Ghamar Talepoor, Zahra Faghih, Nasser Gholijani, Mohammad Reza Ataollahi, Mohammad Ali-Hassanzadeh, Hossein Moravej, Kurosh Kalantar

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. [Research progress and optimization strategies for early screening of type 1 diabetes].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  6. Review
  7. Review
  8. Characterization and effective expansion of CD4Molecular therapy. Methods & clinical development · 2025
    Article
  9. Article
  10. Durable CD4Trends in immunology · 2024
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pooriya FazeliDepartment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Atefe Ghamar TalepoorDepartment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra FaghihShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Nasser GholijaniAutoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Reza AtaollahiDepartment of Immunology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Mohammad Ali-HassanzadehDepartment of Immunology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
Hossein MoravejDepartment of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Kurosh KalantarDepartment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-9160-9449
Shiraz University of Medical Sciences · IRFasa University of Medical Sciences · IRUniversity of Jiroft · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe frequencies and functions of T stem cell memory (TSCM) subsets vary in autoimmune diseases. We evaluated the frequencies of CD4

methodsBlood samples were collected from new case (NC) (n = 15), and long-term (LT) (n = 15) groups and healthy controls (n = 15). Five subsets of T cells including TCM(CD4

resultsThe frequency of CD4

conclusionConsidering TSCMs' capacities to generate all memory and effector T cells, our results may suggest a potential association between the increased frequencies of TSCMs and T1D progression.

Indexed as

Diabetes Mellitus, Type 1Immunologic MemoryCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansProgrammed Cell Death 1 ReceptorReceptors, CCR7Stem CellsProgrammed Cell Death 1 ReceptorReceptors, CCR7autoimmunityCD4 T cellCD8 T cellT memory stem cellstype 1 diabetes

Identifiers

PMID36169248
PMCPMC9500591
OpenAlexW4296828718

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.