Evidence map›Paper›PMID 36169132›Full record

ArticleeLife2022

Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate.

Lyndsey Aponik-Gremillion, Yvonne Y Chen, Eleonora Bartoli, Seth R Koslov, Hernan G Rey, Kevin S Weiner, Daniel Yoshor, Benjamin Y Hayden, Sameer A Sheth, Brett L Foster

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Precise temporal dynamics of ripple events support order memory in human hippocampal-cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Functions of the posterior cingulate cortex and default network.Current opinion in behavioral sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Dissociable Contributions of the Medial Parietal Cortex to Recognition Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Signatures of Electrical Stimulation Driven Network Interactions in the Human Limbic System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. A tripartite view of the posterior cingulate cortex.Nature reviews. Neuroscience · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Lyndsey Aponik-GremillionDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Yvonne Y ChenDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-8844-7891
Eleonora BartoliDepartment of Neurosurgery, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-5824-5065
Seth R KoslovDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-7737-1377
Hernan G ReyDepartment of Neurosurgery, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-6455-8463
Kevin S WeinerDepartment of Psychology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-8734-5049
Daniel YoshorDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Benjamin Y HaydenDepartment of Neuroscience, University of Minnesota, Minneapolis, United States.
Sameer A ShethDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-8770-8965
Brett L FosterDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-2621-5574
University of Pennsylvania · USBaylor College of Medicine · USUniversity of California, Berkeley · USUniversity of Minnesota · USWeber State University · US

Funding

Visual Form Perception Produced by Electrically Stimulating Human Visual CortexR01EY023336 · NEI · UNIVERSITY OF PENNSYLVANIA · PI DANIEL YOSHOR · 2013 to 2026
$5.3M
Posterior cingulate cortex and executive control of episodic memoryR01MH129439 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Brett Foster, BENJAMIN Y HAYDEN · 2022 to 2026
$3.4M
Sensory Reinstatement in Human NeocortexR01MH116914 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FOSTER, BRETT · 2018 to 2022
$2.0M
COGNITIVE CONTROL MECHANISMS IN HUMAN PREFRONTAL CORTEXR01MH106700 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHETH, SAMEER ANIL · 2016 to 2020
$1.6M
The role of prefrontal sulcal morphology and brain network architecture in cognitive developmentR21HD100858 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUNGE, SILVIA A., WEINER, KEVIN SEAN · 2020 to 2021
$375k
Multimodal dissociation of posterior cingulate cortex contributions to episodic memoryF32MH130027 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KOSLOV, SETH RYAN · 2022 to 2024
$236k
NEI NIH HHS R01 EY023336NICHD NIH HHS R21 HD100858NIMH NIH HHS F32 MH130027NIMH NIH HHS R01 MH106700NIMH NIH HHS R01 MH116914NIMH NIH HHS R01 MH129439
6 · The paper itself

Abstract

Posterior cingulate cortex (PCC) is an enigmatic region implicated in psychiatric and neurological disease, yet its role in cognition remains unclear. Human studies link PCC to episodic memory and default mode network (DMN), while findings from the non-human primate emphasize executive processes more associated with the cognitive control network (CCN) in humans. We hypothesized this difference reflects an important functional division between dorsal (executive) and ventral (episodic) PCC. To test this, we utilized human intracranial recordings of population and single unit activity targeting dorsal PCC during an alternated executive/episodic processing task. Dorsal PCC population responses were significantly enhanced for executive, compared to episodic, task conditions, consistent with the CCN. Single unit recordings, however, revealed four distinct functional types with unique executive (CCN) or episodic (DMN) response profiles. Our findings provide critical electrophysiological data from human PCC, bridging incongruent views within and across species, furthering our understanding of PCC function.

Indexed as

Gyrus CinguliMemory, EpisodicBrainBrain MappingCognitionHumansMagnetic Resonance ImagingNeuronscognitive control networkdefault networkepisodic memoryexecutive functionhumanieegneuroscienceposterior cingulate

Identifiers

PMID36169132
PMCPMC9519147
OpenAlexW4297458106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.