Evidence map›Paper›PMID 36168944›Full record

ReviewScandinavian journal of medicine & science in sports2023

IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance.

Dan Nash, Michael G Hughes, Lee Butcher, Rebecca Aicheler, Paul Smith, Tom Cullen, Richard Webb

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Scandinavian journal of medicine & science in sports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 113 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 8 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07632911 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Aerobi̇c and resi̇stance trai̇ni̇ng effects on inflammatory and immune bi̇omarkers i̇n young sedentary women

TypeinterventionalSponsorInonu UniversityRan2025 to 2026Enrolled36ConditionsSedentary BehaviorArmsAerobic and resistance exercise
NCT07726979 nacompletednot on this mapstarted 2024, after this paper: background citation

An Exploration of the Combined Effects of Cordyceps Supplementation and Fartlek Training on Inflammatory, Oxidative Stress, Muscle Damage, and Bone Metabolism Biomarkers (IL-6, IL-10, SOD, MDA, CK, BaLP, OST) in Soccer Players

TypeinterventionalSponsorSurabaya State UniversityRan2024 to 2024Enrolled22ConditionsMuscle Damage, Athletic Performance, Oxidative Stress, InflammationArmsFartlek Training Program, Cordyceps sinensis Supplementation, Placebo
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 8 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dan NashSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0002-6059-1872
Michael G HughesSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
Lee ButcherSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
Rebecca AichelerSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
Paul SmithSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
Tom CullenResearch Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, UK.ORCID https://orcid.org/0000-0002-9058-6716
Richard WebbSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
Cardiff Metropolitan University · GBCoventry University · GB

Funding

European Social Fund
6 · The paper itself

Abstract

The cytokine interleukin-6 (IL-6) is involved in a diverse set of physiological processes. Traditionally, IL-6 has been thought of in terms of its inflammatory actions during the acute phase response and in chronic conditions such as rheumatoid arthritis and obesity. However, IL-6 is also an important signaling molecule during exercise, being acutely released from working muscle fibers with increased exercise duration, intensity, and muscle glycogen depletion. In this context, IL-6 enables muscle-organ crosstalk, facilitating a coordinated response to help maintain muscle energy homeostasis, while also having anti-inflammatory actions. The range of actions of IL-6 can be explained by its dichotomous signaling pathways. Classical signaling involves IL-6 binding to a cell-surface receptor (mbIL-6R; present on only a small number of cell types) and is the predominant signaling mechanism during exercise. Trans-signaling involves IL-6 binding to a soluble version of its receptor (sIL-6R), with the resulting complex having a much greater half-life and the ability to signal in all cell types. Trans-signaling drives the inflammatory actions of IL-6 and is the predominant pathway in disease. A single nucleotide polymorphism (rs2228145) on the IL-6R gene can modify the classical/trans-signaling balance through increasing the levels of sIL-6R. This SNP has clinical significance, having been linked to inflammatory conditions such as rheumatoid arthritis and type 1 diabetes, as well as to the severity of symptoms experienced with COVID-19. This review will describe how acute exercise, chronic training and the rs2228145 SNP can modify the IL-6 signaling pathway and the consequent implications for health and athletic performance.

Indexed as

Arthritis, RheumatoidAthletic PerformanceCOVID-19ExerciseHumansInterleukin-6Interleukin-6Interleukin-6rs2228145sgp130sIL-6R

Identifiers

PMID36168944
PMCPMC10092579
OpenAlexW4297461708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.