ArticleActa obstetricia et gynecologica Scandinavica2022
Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes.
Article in Acta obstetricia et gynecologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Offspring long-term infectious morbidity following pregnancies with cervical cerclage.Archives of gynecology and obstetrics · 2026Article
- Vaginal Microbiota in Short Cervix Pregnancy: Secondary Analysis of Pessary vs. Progesterone Trial.Diseases (Basel, Switzerland) · 2025Article
- The role of cervical microbiome in cervical incompetence: insights from 16 S rRNA metagenomic sequencing.BMC microbiology · 2025Article
- Characteristics of the vaginal microbiota associated with recurrent spontaneous preterm birth: a prospective cohort study.Journal of translational medicine · 2025Article
- The Effect of Probiotics on Preterm Birth Rates in Pregnant Women After a Threatened Preterm Birth Episode (The PROPEV Trial).Biomedicines · 2025Article
- Analysis of the Relationship Between Cervical Cancer Progression and the Microbiome.International journal of general medicine · 2025Article
- Is the Early Screening of Lower Genital Tract Infections Useful in Preventing Adverse Obstetrical Outcomes in Twin Pregnancy?Journal of clinical medicine · 2024Article
- GSR-DB: a manually curated and optimized taxonomical database for 16S rRNA amplicon analysis.mSystems · 2024Article
- Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes.Acta obstetricia et gynecologica Scandinavica · 2022Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOur objective was to compare the vaginal microbiome in low-risk and high-risk pregnant women and to explore a potential association between vaginal microbiome and preterm birth. MATERIAL AND
methodsA pilot, consecutive, longitudinal, multicenter study was conducted in pregnant women at 18-22 weeks of gestation. Participants were assigned to one of three groups: control (normal cervix), pessary (cervical length ≤25 mm) and cerclage (cervical length ≤25 mm or history of preterm birth). Analysis and comparison of vaginal microbiota as a primary outcome was performed at inclusion and at 30 weeks of gestation, along with a follow-up of pregnancy and perinatal outcomes. We assessed the vaginal microbiome of pregnant women presenting a short cervix with that of pregnant women having a normal cervix, and compared the vaginal microbiome of women with a short cervix before and after placement of a cervical pessary or a cervical cerclage.
resultsThe microbiome of our control cohort was dominated by Lactobacillus crispatus and inners. Five community state types were identified and microbiome diversity did not change significantly over 10 weeks in controls. On the other hand, a short cervix was associated with a lower microbial load and higher microbial richness, and was not correlated with Lactobacillus relative abundance. After intervention, the cerclage group (n = 19) had a significant increase in microbial richness and a shift towards community state types driven by various bacterial species, including Lactobacillus mulieris, unidentified Bifidobacterium or Enterococcus. These changes were not significantly observed in the pessary (n = 26) and control (n = 35) groups. The cerclage group had more threatened preterm labor episodes and poorer outcomes than the control and pessary groups.
conclusionsThese findings indicate that a short cervix is associated with an altered vaginal microbiome community structure. The use of a cerclage for preterm birth prevention, as compared with a pessary, was associated with a microbial community harboring a relatively low abundance of Lactobacillus, with more threatened preterm labor episodes, and with poorer clinical outcomes.
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