Evidence map›Paper›PMID 36168854›Full record

ArticleAdvanced healthcare materials2022

3D-Printed Radiopaque Bioresorbable Stents to Improve Device Visualization.

Yonghui Ding, Rao Fu, Caralyn Paige Collins, Sarah-Fatime Yoda, Cheng Sun, Guillermo A Ameer

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. Article
  7. Article
  8. Polydiolcitrate-MoSACS applied materials & interfaces · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. A polydiolcitrate-MoSbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yonghui DingCenter for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0001-5057-9792
Rao FuCenter for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.
Caralyn Paige CollinsCenter for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.
Sarah-Fatime YodaCenter for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.
Cheng SunCenter for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.
Guillermo A AmeerCenter for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular ScaffoldsR01HL141933 · NHLBI · NORTHWESTERN UNIVERSITY · PI Guillermo Antonio Ameer, Cheng Sun · 2019 to 2026
$6.8M
NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL141933NIH HHS R01HL141933
6 · The paper itself

Abstract

Bioresorbable stents (BRS) hold great promise for the treatment of many life-threatening luminal diseases. Tracking and monitoring of stents in vivo is critical for avoiding their malposition and inadequate expansion, which often leads to complications and stent failure. However, obtaining high X-ray visibility of polymeric BRS has been challenging because of their intrinsic radiolucency. This study demonstrates the use of photopolymerization-based 3D printing technique to fabricate radiopaque BRS by incorporating iodixanol, a clinical contrast agent, into a bioresorbable citrate-based polymer ink. The successful volumetric dispersion of the iodixanol through the 3D-printing process confers strong X-ray visibility of the produced BRS. Following in vitro degradation, the 3D-printed BRS embedded in chicken muscle maintains high X-ray visibility for at least 4 weeks. Importantly, the 3D-printed radiopaque BRS demonstrates good cytocompatibility and strong mechanical competence in crimping and expansion, which is essential for minimally invasive stent deployment. In addition, it is found that higher loading concentrations of iodixanol, e.g. 10 wt.%, results in more strut fractures in stent crimping and expansion. To conclude, this study introduces a facile strategy to fabricate radiopaque BRS through the incorporation of iodixanol in the 3D printing process, which could potentially increase the clinical success of BRS.

Indexed as

bioresorbable stentsiodixanolradiopacityX-ray visibility

Identifiers

PMID36168854
PMCPMC9742307

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.