Evidence map›Paper›PMID 36168404›Full record

ArticleThe Lancet regional health. Europe2022

Risk factors for SARS-CoV-2 infection after primary vaccination with ChAdOx1 nCoV-19 or BNT162b2 and after booster vaccination with BNT162b2 or mRNA-1273: A population-based cohort study (COVIDENCE UK).

Giulia Vivaldi, David A Jolliffe, Hayley Holt, Florence Tydeman, Mohammad Talaei, Gwyneth A Davies, Ronan A Lyons, Christopher J Griffiths, Frank Kee, Aziz Sheikh and 2 more

Abstract read
In one paragraph

Article in The Lancet regional health. Europe, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giulia VivaldiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
David A JolliffeBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Hayley HoltBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Florence TydemanBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Mohammad TalaeiWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Gwyneth A DaviesPopulation Data Science, Swansea University Medical School, Singleton Park, Swansea, UK.
Ronan A LyonsPopulation Data Science, Swansea University Medical School, Singleton Park, Swansea, UK.
Christopher J GriffithsWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Frank KeeCentre for Public Health Research (NI), Queen's University Belfast, Belfast, UK.
Aziz SheikhUsher Institute, University of Edinburgh, Edinburgh, UK.
Seif O ShaheenWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Adrian R MartineauBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Little is known about how demographic, behavioural, and vaccine-related factors affect risk of post-vaccination SARS-CoV-2 infection. We aimed to identify risk factors for SARS-CoV-2 infection after primary and booster vaccinations. Methods: This prospective, population-based, UK study in adults (≥16 years) vaccinated against SARS-CoV-2 assessed risk of breakthrough SARS-CoV-2 infection up to February, 2022, for participants who completed a primary vaccination course (ChAdOx1 nCoV-19 or BNT162b2) and those who received a booster dose (BNT162b2 or mRNA-1273). Cox regression models explored associations between sociodemographic, behavioural, clinical, pharmacological, and nutritional factors and test-positive breakthrough infection, adjusted for local weekly SARS-CoV-2 incidence. Findings: 1051 (7·1%) of 14 713 post-primary participants and 1009 (9·5%) of 10 665 post-booster participants reported breakthrough infection, over a median follow-up of 203 days (IQR 195-216) and 85 days (66-103), respectively. Primary vaccination with ChAdOx1 ( Interpretation: Vaccine type, socioeconomic status, age, and behaviours affect risk of breakthrough infection after primary and booster vaccinations. Funding: Barts Charity, UK Research and Innovation Industrial Strategy Challenge Fund.

Indexed as

BNT162b2Breakthrough infectionChAdOx1mRNA-1273SARS-CoV-2Vaccination

Identifiers

PMID36168404
PMCPMC9499825

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.