Evidence map›Paper›PMID 36168122›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes.

Mazin A A Najm, Walaa R Mahmoud, Azza T Taher, Safinaz E-S Abbas, Fadi M Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T Supuran

Abstract read
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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mazin A A NajmDepartment of Pharmaceutical Chemistry, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq.
Walaa R MahmoudDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Azza T TaherDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Safinaz E-S AbbasDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Fadi M AwadallahDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Heba Abdelrasheed AllamDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Daniela VulloDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Claudiu T SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.ORCID 0000-0003-4262-0323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111. Six series of a substituted benzoylthioureido core were prepared featuring different zinc-binding groups; the conventional sulphamoyl group

Indexed as

Carbonic AnhydrasesProdrugsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarboxylic AcidsHumansMolecular StructureStructure-Activity RelationshipZincCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesCarboxylic AcidsProdrugsZincbenzoylthioureido derivativescarbonic anhydraseSLC-0111Sulphonamides

Identifiers

PMID36168122
PMCPMC9542353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.