Evidence map›Paper›PMID 36168088›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2023

Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies.

Raj Shree, Stephen McCartney, Emma Cousin, Angel Chae, Hilary S Gammill, J L Nelson, Sami B Kanaan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. The Microchimerism Literature Atlas.Bioinformatics and biology insights · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Raj ShreeDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA, 98195, USA. shreer23@uw.edu.ORCID http://orcid.org/0000-0002-2747-2097
Stephen McCartneyDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA, 98195, USA.
Emma CousinDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA, 98195, USA.
Angel ChaeDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA, 98195, USA.
Hilary S GammillDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA, 98195, USA.
J L NelsonClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sami B KanaanClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Seattle Pacific University · USUniversity of Washington · USFred Hutch Cancer Center · US

Funding

Microchimerism as AlloImmunityR01HL117737 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NELSON, J. LEE · 2014 to 2018
$2.4M
Cardiovascular disease, preeclampsia, and microchimerismK08HL150169 · NHLBI · UNIVERSITY OF WASHINGTON · PI SHREE, RAJ · 2020 to 2024
$816k
The Maternal Anti-fetal Immune Response & Role of Microchimerism in PreeclamsiaK08HD067221 · NICHD · UNIVERSITY OF WASHINGTON · PI GAMMILL, HILARY SEGLIN · 2012 to 2016
$644k
NHLBI NIH HHS K08 HL150169NHLBI NIH HHS R01 HL117737NICHD NIH HHS K08 HD067221
6 · The paper itself

Abstract

Bidirectional exchange of cells between mother and fetus establishes microchimerism (Mc). Mc can persist for decades and is associated with later-life health and disease. Greater fetal Mc is detected in the maternal compartment in preeclampsia (PE), but whether maternal Mc (MMC) in umbilical cord blood (CB) is altered in PE is unknown. We evaluated MMc in CB from normal and PE pregnancies. DNA from CB mononuclear cells following placental delivery (n = 36 PE, n = 37 controls) and maternal blood was extracted and genotyped. MMc, quantified by qPCR assays targeting maternal-specific nonshared polymorphisms in CB, was compared using logistic and negative binomial regression models. Clinically and statistically relevant confounders were included, and included the total number of cell equivalents tested, gravidity, mode of delivery, birthweight, and fetal sex. PE participants delivered at earlier gestational ages, with higher Cesarean rates, and lower infant birthweights. CB MMc detection was similar between PE and controls (52.8% vs. 51.3%, respectively, p = 0.90) and unchanged after adjustment for confounders. MMc concentration was not different between groups (mean 73.7 gEq/10

Indexed as

PlacentaPre-EclampsiaChimerismFemaleFetal BloodHumansMothersPregnancyUmbilical CordCord bloodMaternal–fetal interfaceMicrochimerismPreeclampsia

Identifiers

PMID36168088
PMCPMC10900989
OpenAlexW4297338214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.