ArticleCommunications biology2022
Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.Biological psychiatry · 2026Article
- Shared cortical morphometry and molecular signatures across depression and physical diseases.Molecular psychiatry · 2026Article
- Neurostimulation in the treatment of psychiatric disorders: Underlying mechanisms and critical analysis of circuit-based interventions.Molecular psychiatry · 2026Review
- Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.Molecular psychiatry · 2026Article
- Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.Molecular psychiatry · 2026Article
- Cortical Structure in Relation to Empathy and Psychopathy in 800 Incarcerated Men.Biological psychiatry global open science · 2026Article
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.bioRxiv : the preprint server for biology · 2026Article
- Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum.Schizophrenia bulletin · 2026Article
- Associations between epilepsy-related polygenic risk and brain morphology in childhood.Brain : a journal of neurology · 2026Article
- Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment.Human brain mapping · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Hierarchical reorganization of cortical and cerebellar functional gradients in Parkinson's disease.Frontiers in neurology · 2026Article
- Cortical structure in relation to empathy and psychopathy in 800 incarcerated men.bioRxiv : the preprint server for biology · 2025Article
- Exploring dopamine as the master regulator of brain circuitry and mental health genome.Gene & protein in disease · 2025Article
- Brain Structural Correlates of EEG Network Hyperexcitability, Symptom Severity, Attention, and Memory in Borderline Personality Disorder.Brain sciences · 2025Article
- Advanced concentrative absorption meditation reorganizes functional connectivity gradients of the brain: 7T MRI and phenomenology case study of jhana meditation.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity.Scientific reports · 2025Article
- The possibilities of conscious experience in light of the dual origin hypothesis of the neocortex.Neuroscience of consciousness · 2025Article
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Authors and funding
24 authors.
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Abstract
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we identified a cortex-wide dimension of morphological changes that described a sensory-fugal pattern, with paralimbic regions showing the most consistent alterations across conditions. The shared disease dimension was closely related to cortical gradients of microstructure as well as neurotransmitter axes, specifically cortex-wide variations in serotonin and dopamine. Multiple sensitivity analyses confirmed robustness with respect to slight variations in analytical choices. Our findings embed shared effects of common psychiatric conditions on brain structure in multiple scales of brain organization, and may provide insights into neural mechanisms of transdiagnostic vulnerability.
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