ArticleScientific reports2022
A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Unintended right atrial lesions after monopolar biphasic lattice-tip pulsed-field ablation: a case series.European heart journal. Case reports · 2026Article
- Pulsed Field Ablation Therapy Parameters: Enhancing Lesion Depth While Reducing Musculoskeletal Stimulation and Thermal Response in an Irrigated Tip Catheter: A Comprehensive Study Using In Silico, In Vitro, and In Vivo Models.Circulation. Arrhythmia and electrophysiology · 2026Article
- Nonidiopathic papillary muscle ventricular arrhythmia ablation using the lattice-tip catheter: A case series.HeartRhythm case reports · 2026Article
- Microbubble and thermal profile of an eight-spline pulsed field ablation system in a pre-clinical model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- The potato model: A root of all pulsed field ablation experimentation?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Permanent Heart Block Complicating Pulsed-Field Ablation of the Cavotricuspid Isthmus.JACC. Case reports · 2026Article
- Inflammatory and Myocardial Biomarker Response Following Pulmonary Vein Isolation: Cryoballoon Versus Balloon-in-Basket Pulsed Field Ablation.Journal of cardiovascular electrophysiology · 2026Article
- Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report.Frontiers in cardiovascular medicine · 2026Article
- Ablation Methods and Catheter Settings for Ventricular Tachycardia Ablation: A Bench to Bedside Review: Part 1.Arrhythmia & electrophysiology review · 2026Review
- Differential inflammatory and myocardial biomarker response after pulsed field ablation for atrial fibrillation using balloon-in-basket vs pentaspline catheters.Heart rhythm O2 · 2025Article
- Cardiac biomarker temporal dynamics after radiofrequency and pulsed field catheter ablation of atrial fibrillation.Heart rhythm O2 · 2025Article
- Role of Computational Modelling in Enhancing Thermal Safety During Cardiac Ablation.Interdisciplinary cardiovascular and thoracic surgery · 2025Review
- Computational Multiscale Modeling of Pulsed Field Ablation Considering Conductivity and Damage Anisotropy Reveals Deep Lesion Morphologies.International journal for numerical methods in biomedical engineering · 2025Article
- Pulsed electric field ablation process-the effect of bifurcation stents on electric field and heat distribution.Scientific reports · 2025Article
- De novo ventricular tachycardia ablation with stacked pulsed-field and radiofrequency energy via a dual-energy lattice-tipped catheter.HeartRhythm case reports · 2025Article
- Is a single lethal electric field threshold sufficient to characterize the lesion size in computational modeling of cardiac pulsed-field ablation?Heart rhythm O2 · 2025Article
- Pulsed field ablation for atrial fibrillation: clinical applications and research advances.Frontiers in cardiovascular medicine · 2025Review
- Computer modelling and vegetable bench test of a bipolar electrode array intended for use in high frequency irreversible electroporation treatment of skin cancer.Biomedical engineering letters · 2025Article
- Pulsed electric field ablation process-a study of the effect of different shapes (materials) of metal stents on the ablation effect.Frontiers in cardiovascular medicine · 2025Article
- Durability of Pulsed Field Ablation Lesions: Current Understanding and Future Directions.Arrhythmia & electrophysiology review · 2025Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pulsed Field Ablation (PFA) has been developed over the last years as a novel electrical ablation technique for treating cardiac arrhythmias. It is based on irreversible electroporation which is a non-thermal phenomenon innocuous to the extracellular matrix and, because of that, PFA is considered to be safer than the reference technique, Radiofrequency Ablation (RFA). However, possible differences in lesion morphology between both techniques have been poorly studied. Simulations including electric, thermal and fluid physics were performed in a simplified model of the cardiac chamber which, in essence, consisted of a slab of myocardium with blood in motion on the top. Monopolar and bipolar catheter configurations were studied. Different blood velocities and catheter orientations were assayed. RFA was simulated assuming a conventional temperature-controlled approach. The PFA treatment was assumed to consist in a sequence of 20 biphasic bursts (100 µs duration). Simulations indicate that, for equivalent lesion depths, PFA lesions are wider, larger and more symmetrical than RFA lesions for both catheter configurations. RFA lesions display a great dependence on blood velocity while PFA lesions dependence is negligible on it. For the monopolar configuration, catheter angle with respect to the cardiac surface impacted both ablation techniques but in opposite sense. The orientation of the catheter with respect to blood flow direction only affected RFA lesions. In this study, substantial morphological differences between RFA and PFA lesions were predicted numerically. Negligible dependence of PFA on blood flow velocity and direction is a potential important advantage of this technique over RFA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.