Evidence map›Paper›PMID 36167862›Full record

ArticleCellular and molecular life sciences : CMLS2022

Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites.

Kusumika Saha, Benoit Chevalier, Stéphane Doly, Nesrine Baatallah, Thomas Guilbert, Iwona Pranke, Mark G H Scott, Hervé Enslen, Chiara Guerrera, Cérina Chuon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kusumika SahaUniversité Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR 8104, 75014, Paris, France.
Benoit ChevalierInstitut-Necker-Enfants-Malades, Université Paris Cité, INSERM U1151, CNRS UMR 8253, 75015, Paris, France.
Stéphane DolyUniversité Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR 8104, 75014, Paris, France.
Nesrine BaatallahInstitut-Necker-Enfants-Malades, Université Paris Cité, INSERM U1151, CNRS UMR 8253, 75015, Paris, France.
Thomas GuilbertUniversité Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR 8104, 75014, Paris, France.
Iwona PrankeInstitut-Necker-Enfants-Malades, Université Paris Cité, INSERM U1151, CNRS UMR 8253, 75015, Paris, France.
Mark G H ScottUniversité Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR 8104, 75014, Paris, France.
Hervé EnslenUniversité Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR 8104, 75014, Paris, France.
Chiara GuerreraProteomic Facility, Institut-Necker-Enfants-Malades, Université Paris Cité, 75015, Paris, France.
Cérina ChuonProteomic Facility, Institut-Necker-Enfants-Malades, Université Paris Cité, 75015, Paris, France.
Aleksander EdelmanInstitut-Necker-Enfants-Malades, Université Paris Cité, INSERM U1151, CNRS UMR 8253, 75015, Paris, France.
Isabelle Sermet-GaudelusInstitut-Necker-Enfants-Malades, Université Paris Cité, INSERM U1151, CNRS UMR 8253, 75015, Paris, France.
Alexandre Hinzpeter *Institut-Necker-Enfants-Malades, Université Paris Cité, INSERM U1151, CNRS UMR 8253, 75015, Paris, France.
Stefano Marullo *Université Paris Cité, Institut Cochin, INSERM U1016, CNRS UMR 8104, 75014, Paris, France. stefano.marullo@inserm.fr.ORCID http://orcid.org/0000-0001-9604-9973

Funding

Agence nationale pour la Recherche ANR-10-INBS-04Agence Nationale pour la Recherche ANR-18-CE14-0004-02Fondation Vaincre la Mucoviscidose RF20180502279
6 · The paper itself

Abstract

The endoplasmic reticulum exit of some polytopic plasma membrane proteins (PMPs) is controlled by arginin-based retention motifs. PRAF2, a gatekeeper which recognizes these motifs, was shown to retain the GABA

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorCarrier ProteinsCell MembraneEndoplasmic Reticulumgamma-Aminobutyric AcidHumansMembrane ProteinsMutationCarrier ProteinsCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulatorgamma-Aminobutyric AcidMembrane ProteinsPRAF2 protein, humanArginin-based retention motifBRETCFTRCorrectorERESGatekeeperProtein exportSec 24Sec 31

Identifiers

PMID36167862
PMCPMC11802960

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.