ArticleNature communications2022
The transcription factor Zfh1 acts as a wing-morph switch in planthoppers.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A glucose-AMPK-FoxO-vestigial signaling axis underlies host sugar-mediated wing dimorphism in Laodelphax striatellus.Pest management science · 2026Article
- Transcriptomic basis underlying the evolution of female horn plasticity in scarab beetles.Frontiers in zoology · 2026Article
- The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid.iScience · 2025Article
- Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form ofeLife · 2024Article
- Evolution and molecular mechanisms of wing plasticity in aphids.Current opinion in insect science · 2024Review
- A plant virus manipulates the long-winged morph of insect vectors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gene regulatory networks underlying the development and evolution of plasticity in horned beetles.Current opinion in insect science · 2023Review
- miR-252 targeting temperature receptoreLife · 2023Article
- Article
- One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects.Biochemical Society transactions · 2023Review
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Authors and funding
5 authors.
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Abstract
Insect wing polyphenism is characterized by its ability to produce two or more distinct wing morphs from a single genotype in response to changing environments. However, the molecular basis of this phenomenon remains poorly understood. Here, we identified a zinc finger homeodomain transcription factor Zfh1 that acts as an upstream regulator for the development of long-winged (LW) or shorted-winged (SW) morphs in planthoppers. Knockdown of Zfh1 directs SW-destined nymphs to develop into LW morphs by down-regulating the transcriptional level of FoxO, a prominent downstream effector of the insulin/IGF signaling (IIS) pathway. The balance between transcriptional regulation via the Zfh1-FoxO cascade and post-translational regulation via the IIS-FoxO cascade provides a flexible regulatory mechanism for the development of alternative wing morphs. These findings help us understand how phenotypic diversity is generated by altering the activity of conserved proteins, and provide an extended framework for the evolution of wing morphological diversity in insects.
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