Evidence map›Paper›PMID 36167734›Full record

ArticleScientific reports2022

Microwave induced thermally assisted solvent-based bonding of biodegradable thermoplastics: an eco-friendly rapid approach for fabrication of microfluidic devices and analyte detection.

Md Sadique Hasan, Shayan Borhani, Sai Sathish Ramamurthy, Abhay Andar, Xudong Ge, Fow-Sen Choa, Yordan Kostov, Govind Rao

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Md Sadique HasanCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Shayan BorhaniCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Sai Sathish RamamurthyCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Abhay AndarCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Xudong GeCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Fow-Sen ChoaDepartment of Computer Science and Electrical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Yordan KostovCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA.
Govind RaoCenter for Advanced Sensor Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MA, 21250, USA. grao@umbc.edu.

Funding

FDA HHS BAA 75F40119C10132
6 · The paper itself

Abstract

There is an increasing interest in low-cost, facile and versatile thermoplastic bonding for microfluidic applications that can be easily transitioned from laboratory prototyping to industrial manufacturing. In addition, owing to the surge in the usage of thermoplastic microfluidics and its adverse effect on the environment, it is prudent to source alternative materials that are biodegradable, providing a sustainable, green approach. To address the problems, here we introduce an environment friendly, low-cost and safe welding technology used in the fabrication of microcassettes from biodegradable cellulose acetate (CA) thermoplastics. The thermally assisted solvent based bonding of the thermoplastics was accomplished in a domestic microwave oven with the aid of a polyether ether ketone (PEEK) vise. To characterize the quality of the bonding, our in-house technique was compared with a conventional thermally assisted solvent bonding configuration using a heat press machine and tested under different conditions. Our microwave induced bonding of CA presents three times reduced bonding time with higher bonding strength, good reliability and does not necessitate the use of cumbersome instrumentation. Finally, we demonstrate an electrophoresis application and vitamin C detection accomplished using this biodegradable microcassette presenting comparable results with traditional techniques, illustrating the potential of this fabrication technique in different microfluidic applications.

Indexed as

Lab-On-A-Chip DevicesMicrofluidic Analytical TechniquesAscorbic AcidEthersKetonesMicrowavesReproducibility of ResultsSolventsAscorbic AcidEthersKetonesSolvents

Identifiers

PMID36167734
PMCPMC9515109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.