Evidence map›Paper›PMID 36167624›Full record

ArticleAmerican journal of surgery2023

Reclassification of CKD in living kidney donors with the refitted race-free eGFR formula.

Babak J Orandi, Vineeta Kumar, Rhiannon D Reed, Paul A MacLennan, Brittany A Shelton, Chandler McLeod, Jayme E Locke

Open access · greenAbstract read
In one paragraph

Article in American journal of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Babak J OrandiUniversity of Alabama at Birmingham, Department of Surgery, Division of Transplantation, Birmingham, AL, USA.
Vineeta KumarUniversity of Alabama at Birmingham, Department of Medicine, Division of Nephrology, Birmingham, AL, USA.
Rhiannon D ReedUniversity of Alabama at Birmingham, Department of Surgery, Division of Transplantation, Birmingham, AL, USA.
Paul A MacLennanUniversity of Alabama at Birmingham, Department of Surgery, Division of Transplantation, Birmingham, AL, USA.
Brittany A SheltonUniversity of Alabama at Birmingham, Department of Surgery, Division of Transplantation, Birmingham, AL, USA.
Chandler McLeodUniversity of Alabama at Birmingham, Department of Surgery, Division of Transplantation, Birmingham, AL, USA.
Jayme E LockeUniversity of Alabama at Birmingham, Department of Surgery, Division of Transplantation, Birmingham, AL, USA. Electronic address: jlocke@uabmc.edu.
University of Alabama at Birmingham · US

Funding

CKD Risk Prediction among Obese Living Kidney DonorsR01DK113980 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCKE, JAYME ELIZABETH · 2018 to 2022
$3.4M
NIDDK NIH HHS R01 DK113980
6 · The paper itself

Abstract

backgroundChronic Kidney Disease (CKD) Epidemiology Collaboration eGFR 2021 formula removed Black race from the 2009 equation. Unintended consequences may lead to reclassifying Black living kidney donors as having more advanced CKD, exacerbating racial disparities in living donation.

methodsWe used national data to quantify CKD stage reclassification based on eGFR for Black living donors both pre- and post-donation.

resultsAmong 6365 Black living donors, 17.7% were reclassified as having a higher CKD stage pre-donation with the 2021 formula. Among 4149 Black living donors with at least 2 creatinine measurements post-donation, 25.5% were reclassified as having a higher CKD stage post-donation with the 2021 formula.

conclusionEliminating race in the formula may inappropriately label Black potential donors with CKD. These data highlight the need for a validated eGFR formula for donors, use of measured and not eGFR, and education of non-transplant providers regarding interpretation of CKD staging in living donation.

Indexed as

Kidney TransplantationRenal Insufficiency, ChronicCreatinineGlomerular Filtration RateHumansKidneyLiving DonorsCreatinine

Identifiers

PMID36167624
PMCPMC9998335
OpenAlexW4296903079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.