Evidence map›Paper›PMID 36167610›Full record

Trial reportInternational dental journal2023

Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy.

Evelina Alkimavičienė, Rasa Pušinskaitė, Nomeda Basevičienė, Rasa Banienė, Nijolė Savickienė, Ingrida Marija Pacauskienė

Open access · goldFull text readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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  3. Article
  4. Review
  5. Review
  6. Application of collagen in bone regeneration.Journal of orthopaedic translation · 2025
    Review
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Evelina AlkimavičienėDepartment of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: evelina.alkimaviciene@lsmu.lt.
Rasa PušinskaitėDepartment of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Nomeda BasevičienėDepartment of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Rasa BanienėDepartment of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Nijolė SavickienėDepartment of Pharmacognosy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ingrida Marija PacauskienėDepartment of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this work was to evaluate the efficacy of proanthocyanidins (PACNs) as an adjunctive periodontal therapy in patients with periodontitis.

methodsPatients with periodontitis (stage III-IV) were included in this randomised clinical study. Patients with periodontitis received 2 different treatment modalities: minimally invasive nonsurgical therapy only (MINST group) or minimally invasive nonsurgical therapy and subgingival application of collagen hydrogels with PACNs (MINST + PACNs group). Clinical periodontal parameters, that is, pocket probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), were evaluated before treatment and after 8 weeks. Concentrations of immunologic markers, matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in saliva were assessed at baseline and at 8-week follow-up.

resultsForty-six patients diagnosed with periodontitis were randomised into 2 groups: 23 patients in the MINST group and 23 patients in the MINST + PACNs group received the intended treatment. PACNs combined with MINST resulted in additional statistically significant PPD reduction and CAL gain in moderate periodontal pockets by 0.5 mm (P < .05) on average compared to MINST alone. Additional use of PACNs did not result in additional statistically significant improvement of BOP or PI values. Application of PACNs showed significant reduction of MMP-3 levels in saliva after 8 weeks (P < .05).

conclusionsAdjunctive use of PACNs in MINST resulted in better clinical outcomes for moderate pockets. Additional use of PACNs improved MMP-3 concentration in saliva more than MINST alone. Biochemical analysis revealed that MMP-3 concentration in saliva reflected the periodontal health state.

Indexed as

Chronic PeriodontitisPeriodontitisProanthocyanidinsDental ScalingHumansMatrix Metalloproteinase 3Vasculitis, Central Nervous SystemMatrix Metalloproteinase 3ProanthocyanidinsPeriodontal debridementPeriodontitisProanthocyanidinsRandomised controlled trial

Identifiers

PMID36167610
PMCPMC10023589
OpenAlexW4297180538

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.