Evidence map›Paper›PMID 36167574›Full record

ArticleTrials2022

Effect of anesthesia on the outcome of high-grade glioma patients undergoing supratentorial resection: study protocol for a pragmatic randomized controlled trial.

Jia Dong, Dexiang Wang, Huizhong Sun, Min Zeng, Xiaoyuan Liu, Xiang Yan, Ruowen Li, Shu Li, Yuming Peng

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02756312 (The Impact of Anesthesia on the Outcome of Supratentorial High- Grade Glioma Patients After Craniotomy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02756312 naunknown statusnot on this map

The Impact of Anesthesia on the Outcome of Supratentorial High- Grade Glioma Patients After Craniotomy

TypeinterventionalSponsorBeijing Tiantan HospitalRan2020 to 2022Enrolled196ConditionsAnesthesia, Outcome, High-grade GliomaArmsIV Anesthesia, IH anesthesia
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jia DongDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Dexiang WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Huizhong SunDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Min ZengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Xiaoyuan LiuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Xiang YanDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Ruowen LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Shu LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Yuming PengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. florapym766@163.com.ORCID http://orcid.org/0000-0002-2630-2467
Capital Medical University · CN

Funding

the Scientific Research and Cultivation Plan of Beijing Municipal Administration of Hospitals PX2019018
6 · The paper itself

Abstract

backgroundHigh-grade glioma (HGG) is the most malignant brain tumor with poor outcomes. Whether anesthetic methods have an impact on the outcome of these patients is still unknown. Retrospective study has found no difference between intravenous and inhalation anesthesia on the overall survival (OS) of the HGG patients, however, intravenous anesthesia with propofol might be beneficial in a subgroup of patients with a Karnofsky Performance Status (KPS) Scale less than 80. Further prospective studies are needed to evaluate the results.

methodsThis is a single-centered, randomized controlled, parallel-group trial. Three hundred forty-four patients with primary HGG for tumor resection will be randomly assigned to receive either intravenous anesthesia with propofol or inhalation anesthesia with sevoflurane. The primary outcome is the OS of the patients within 18 months. Secondary outcomes include progression-free survival (PFS), the numerical rating scale (NRS) of pain intensity and sleep quality, the postoperative encephaloedema volume, complications, and the length of hospital stay of the patients. DISCUSSION: This is a randomized controlled trial to compare the effect of intravenous and inhalation anesthesia maintenance on the outcome of supratentorial HGG patients. The results will contribute to optimizing the anesthesia methods in these patients.

trial registrationClinicalTrials.gov NCT02756312. Registered on 29 April 2016 and last updated on 9 Sep 2020.

Indexed as

Anesthetics, InhalationGliomaPropofolAnesthesia, InhalationAnesthetics, IntravenousHumansPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicRetrospective StudiesSevofluraneAnesthetics, InhalationAnesthetics, IntravenousPropofolSevofluraneAnesthesiaHigh-grade gliomaSurvival

Identifiers

PMID36167574
PMCPMC9513932
OpenAlexW4297199982

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.