Evidence map›Paper›PMID 36167555›Full record

Trial reportTrials2022

Targeted AntiBiotics for Chronic pulmonary diseases (TARGET ABC): can targeted antibiotic therapy improve the prognosis of Pseudomonas aeruginosa-infected patients with chronic pulmonary obstructive disease, non-cystic fibrosis bronchiectasis, and asthma? A multicenter, randomized, controlled, open-label trial.

Josefin Eklöf, Imane Achir Alispahic, Pradeesh Sivapalan, Torgny Wilcke, Niels Seersholm, Karin Armbruster, Jakob Lyngby Kjærgaard, Mohamad Isam Saeed, Thyge Lynghøj Nielsen, Andrea Browatzki and 29 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03262142 (Targeted AntiBiotics for Chronic Pulmonary Disease), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03262142 phase4terminatednot on this map

Targeted AntiBiotics for Chronic Pulmonary Disease: Can Targeted Antibiotic Therapy Improve the Prognosis of Pseudomonas Aeruginosa Infected Patients With Chronic Pulmonary Obstructive Disease, Non-cystic Fibrosis Bronchiectasis and Asthma? A Multicenter, Randomized, Controlled, Open-label Trial.

TypeinterventionalSponsorChronic Obstructive Pulmonary Disease Trial Network, DenmarkRan2018 to 2023Enrolled51ConditionsCOPD, Respiratory Tract Infections, Pseudomonas Aeruginosa, BronchiectasisArmsPiperacillin/tazobactam, Ciprofloxacin
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Anti-Microorganisms · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 11 institutions in 1 country.

Josefin EklöfDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Imane Achir AlispahicDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. imane.achir.alispahic@regionh.dk.
Pradeesh SivapalanDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Torgny WilckeDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Niels SeersholmDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Karin ArmbrusterDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jakob Lyngby KjærgaardDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Mohamad Isam SaeedDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Thyge Lynghøj NielsenDepartment of Respiratory and Infectious Diseases, Frederikssund and Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark.
Andrea BrowatzkiDepartment of Respiratory and Infectious Diseases, Frederikssund and Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark.
Rikke Holmen OvergaardDepartment of Respiratory and Infectious Diseases, Frederikssund and Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark.
Camilla Sund FenlevDepartment of Respiratory and Infectious Diseases, Frederikssund and Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark.
Zitta Barella HarboeDepartment of Respiratory and Infectious Diseases, Frederikssund and Hillerød Hospital, University of Copenhagen, Copenhagen, Denmark.
Helle Frost AndreassenDepartment of Respiratory Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Therese Sophie LapperreDepartment of Respiratory Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Lars PedersenDepartment of Respiratory Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Stine JohnsenDepartment of Respiratory Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Amager and Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Julie JannerDepartment of Respiratory Medicine, Amager and Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Mia MobergDepartment of Respiratory Medicine, Amager and Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Maria HeidemannDepartment of Respiratory Medicine, Amager and Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Ulla Møller WeinreichDepartment of Respiratory Medicine, Aalborg University Hospital, University of Aalborg, Aalborg, Denmark.
Roxana VijdeaDepartment of Respiratory Medicine, Aalborg University Hospital, University of Aalborg, Aalborg, Denmark.
Hans LindeDepartment of Clinical Microbiology, Aalborg University Hospital, University of Aalborg, Aalborg, Denmark.
Ingrid TitlestadDepartment of Respiratory Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Sofie Lock JohanssonDepartment of Respiratory Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Flemming Schønning RosenvingeDepartment of Clinical Microbiology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Christian ØstergaardDepartment of Clinical Microbiology, Amager and Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Khaled Saoud Ali GhathianDepartment of Clinical Microbiology, Amager and Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Lise GundersenDepartment of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Christina Wellendorph ChristensenDepartment of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jette BangsborgDepartment of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Torben Tranborg JensenDepartment of Internal Medicine, Section of Respiratory Medicine, Hospital of South West Jutland, Esbjerg, Denmark.
Vibeke Muff SørensenDepartment of Internal Medicine, Section of Respiratory Medicine, Hospital of South West Jutland, Esbjerg, Denmark.
Thilde EllingsgaardDepartment of Internal Medicine, Section of Respiratory Medicine, Hospital of South West Jutland, Esbjerg, Denmark.
Raluca DatcuDepartment of Clinical Microbiology, Hospital of South West Jutland, Esbjerg, Denmark.
John Eugenio CoiaDepartment of Clinical Microbiology, Hospital of South West Jutland, Esbjerg, Denmark.
Uffe BodtgerDepartment of Internal Medicine, Zealand Hospital, University of Copenhagen, Roskilde, Denmark.
Jens Ulrik Stæhr JensenDepartment of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKGentofte Hospital · DKHospital South West Jutland · DKHvidovre Hospital · DKAalborg University Hospital · DKOdense University Hospital · DKAmager Hospital · DKBispebjerg Hospital · DKNæstved Sygehus · DKUniversity of Southern Denmark · DKZealand University Hospital · DK

Funding

Danmarks Frie Forskningsfond 8020-00425B
6 · The paper itself

Abstract

backgroundPseudomonas aeruginosa infection is seen in chronic pulmonary disease and is associated with exacerbations and poor long-term prognosis. However, evidence-based guidelines for the management and treatment of P. aeruginosa infection in chronic, non-cystic fibrosis (CF) pulmonary disease are lacking. The aim of this study is to investigate whether targeted antibiotic treatment against P. aeruginosa can reduce exacerbations and mortality in patients with chronic obstructive pulmonary disease (COPD), non-CF bronchiectasis, and asthma.

methodsThis study is an ongoing multicenter, randomized, controlled, open-label trial. A total of 150 patients with COPD, non-CF bronchiectasis or asthma, and P. aeruginosa-positive lower respiratory tract samples will be randomly assigned with a 1:1 ratio to either no antibiotic treatment or anti-pseudomonal antibiotic treatment with intravenous beta-lactam and oral ciprofloxacin for 14 days. The primary outcome, analyzed with two co-primary endpoints, is (i) time to prednisolone and/or antibiotic requiring exacerbation or death, in the primary or secondary health sector, within days 20-365 from study allocation and (ii) days alive and without exacerbation within days 20-365 from the study allocation. DISCUSSION: This trial will determine whether targeted antibiotics can benefit future patients with chronic, non-CF pulmonary disease and P. aeruginosa infection in terms of reduced morbidity and mortality, thus optimizing therapeutic approaches in this large group of chronic patients.

trial registrationClinicalTrials.gov NCT03262142 . Registered on August 25, 2017.

Indexed as

AsthmaBronchiectasisPulmonary Disease, Chronic ObstructiveAnti-Bacterial Agentsbeta-LactamsCiprofloxacinFibrosisHumansPrednisolonePrognosisPseudomonas aeruginosaAnti-Bacterial Agentsbeta-LactamsCiprofloxacinPrednisoloneAntibioticsAsthmaChronic obstructive pulmonary diseaseNon-CF bronchiectasisPseudomonas aeruginosaRandomized controlled trial

Identifiers

PMID36167555
PMCPMC9513970
OpenAlexW4297425788

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.