Observational studyCritical care (London, England)2022
Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients: a retrospective multicenter study.
Observational study in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Comparative analysis of ventilator-associated pneumonia and ventilator-associated event surveillance systems: a retrospective observational study.Journal of Korean biological nursing science · 2026Article
- Risk factors, predictive biomarkers, and microbial profile of ventilator-associated pneumonia in critically ill patients: a retrospective cohort Study.BMC pulmonary medicine · 2026Article
- Stress hyperglycemia ratio in risk stratification and treatment optimization for patients on invasive mechanical ventilation: a secondary analysis of the MIMIC-IV database.BMC infectious diseases · 2026Article
- Corticosteroids and hospital-acquired pneumonia.Pneumonia (Nathan Qld.) · 2025Review
- Advocating for the recognition of underlying immunosuppression in critical illness.EClinicalMedicine · 2025Review
- Early bacterial co-infections and ventilator-associated lower respiratory tract infections among intubated patients during the first and second COVID-19 waves: a European comparative cohort study.Respiratory research · 2025Article
- Incidence and risk factors of ventilator-associated pneumonia in the intensive care unit: a systematic review and meta-analysis.Journal of thoracic disease · 2024Article
- Intensive care unit-acquired infections more common in patients with COVID-19 than with influenza.Scientific reports · 2024Article
- ICU-Acquired Colonization and Infection Related to Multidrug-Resistant Bacteria in COVID-19 Patients: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Relationship between COVID-19 and ICU-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter before-after study.Intensive care medicine · 2023Observational
- Replicating finding, answering questions: closer to the truth about COVID-19 associated VAP.Critical care (London, England) · 2023Article
- "Reply on: statistics on steroids-how recognizing competing risks gets us closer to the truth about COVID-19-associated VAP".Critical care (London, England) · 2023Article
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 7 countries.
Funding
Abstract
backgroundVentilator-associated pneumonia (VAP) is common in patients with severe SARS-CoV-2 pneumonia. The aim of this ancillary analysis of the coVAPid multicenter observational retrospective study is to assess the relationship between adjuvant corticosteroid use and the incidence of VAP.
methodsPlanned ancillary analysis of a multicenter retrospective European cohort in 36 ICUs. Adult patients receiving invasive mechanical ventilation for more than 48 h for SARS-CoV-2 pneumonia were consecutively included between February and May 2020. VAP diagnosis required strict definition with clinical, radiological and quantitative microbiological confirmation. We assessed the association of VAP with corticosteroid treatment using univariate and multivariate cause-specific Cox's proportional hazard models with adjustment on pre-specified confounders.
resultsAmong the 545 included patients, 191 (35%) received corticosteroids. The proportional hazard assumption for the effect of corticosteroids on the incidence of VAP could not be accepted, indicating that this effect varied during ICU stay. We found a non-significant lower risk of VAP for corticosteroid-treated patients during the first days in the ICU and an increased risk for longer ICU stay. By modeling the effect of corticosteroids with time-dependent coefficients, the association between corticosteroids and the incidence of VAP was not significant (overall effect p = 0.082), with time-dependent hazard ratios (95% confidence interval) of 0.47 (0.17-1.31) at day 2, 0.95 (0.63-1.42) at day 7, 1.48 (1.01-2.16) at day 14 and 1.94 (1.09-3.46) at day 21.
conclusionsNo significant association was found between adjuvant corticosteroid treatment and the incidence of VAP, although a time-varying effect of corticosteroids was identified along the 28-day follow-up.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.