Evidence map›Paper›PMID 36167472›Full record

Observational studyBMJ open respiratory research2022

Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers.

Sebastian T Lugg, William R Mackay, Aduragbemi A Faniyi, Sian E Faustini, Craig Webster, Joanne E Duffy, Martin Hewison, Adrian M Shields, Dhruv Parekh, Alex G Richter and 2 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sebastian T LuggInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
William R MackayInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Aduragbemi A FaniyiInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Sian E FaustiniInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Craig WebsterDepartment of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Joanne E DuffyDepartment of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Martin HewisonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Adrian M ShieldsInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Dhruv ParekhInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1508-8362
Alex G RichterInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Aaron ScottInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
David R ThickettInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK d.thickett@bham.ac.uk.
University of Birmingham · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

Department of HealthMedical Research Council MR/S002782/1Wellcome Trust
6 · The paper itself

Abstract

backgroundThere is increasing evidence that vitamin D (VD) deficiency may increase individuals' risk of COVID-19 infection and susceptibility. We aimed to determine the relationship between VD deficiency and sufficiency and COVID-19 seropositivity within healthcare workers.

methodsThe study included an observational cohort of healthcare workers who isolated due to COVID-19 symptoms from 12 May to 22 May 2020, from the University Hospitals Birmingham National Health Service Foundation Trust. Data collected included SARS-CoV-2 seroconversion status, serum 25(OH)D

resultsWhen VD levels were compared against COVID-19 seropositivity rate, a U-shaped curve was identified. This trend repeated when participants were split into subgroups of age, sex, ethnicity, BMI and comorbidity status. Significant difference was identified in the COVID-19 seropositivity rate between VD groups in the total population and between groups of men and women; black, Asian and minority ethnic (BAME) group; BMI<30 (kg/m

conclusionsOur study has shown a U-shaped relationship for COVID-19 seropositivity in UK healthcare workers. Further investigation is required to determine whether high VD levels can have a detrimental effect on susceptibility to COVID-19 infection. Future randomised clinical trials of VD supplementation could potentially identify 'optimal' VD levels, allowing for targeted therapeutic treatment for those at risk.

Indexed as

COVID-19Vitamin D DeficiencyFemaleHealth PersonnelHumansMaleSARS-CoV-2State MedicineUnited KingdomVitamin DVitamin DCOVID-19respiratory infectionviral infection

Identifiers

PMID36167472
PMCPMC9515459
OpenAlexW4297322401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.