Evidence map›Paper›PMID 36167470›Full record

ArticleGenes & development2022

Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells.

Rebecca J Burgess, Zhiyu Zhao, Daisuke Nakada, Sean J Morrison

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. mRNA translational control of regeneration.Current opinion in genetics & development · 2025
    Review
  4. The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia.Biochimica et biophysica acta. Molecular basis of disease · 2024
    Article
  5. Expansion of human hematopoietic stem cells by inhibiting translation.bioRxiv : the preprint server for biology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Rebecca J BurgessChildren's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Zhiyu ZhaoChildren's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Daisuke NakadaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.
Sean J MorrisonChildren's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
The University of Texas Southwestern Medical Center · USBaylor College of Medicine · USHoward Hughes Medical Institute · US

Funding

The Regulation of Stem Cell AgingR37AG024945 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2009 to 2018
$3.1M
The Metabolic Regulation of Hematopoietic Stem Cell FunctionR01DK118745 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2019 to 2023
$1.8M
The Regulation of Stem Cell AgingR01AG024945 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORRISON, SEAN J · 2004 to 2008
$1.1M
The role of proline dehydrogenase in hematopoietic stem cell functionF32HL122095 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, REBECCA JODELLE · 2014 to 2016
$164k
The metabolic regulation of hematopoietic stem cell functionR56DK118745 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2018 to 2018
$100k
NHLBI NIH HHS F32 HL122095NIA NIH HHS R01 AG024945NIA NIH HHS R37 AG024945NIDDK NIH HHS R01 DK118745NIDDK NIH HHS R56 DK118745
6 · The paper itself

Abstract

The polycomb complex component Bmi1 promotes the maintenance of stem cells in multiple postnatal tissues, partly by negatively regulating the expression of p16

Indexed as

Cyclin-Dependent Kinase Inhibitor p16ProteostasisHematopoietic Stem CellsPolycomb Repressive Complex 1Protein AggregatesProto-Oncogene ProteinsRNA, RibosomalCyclin-Dependent Kinase Inhibitor p16Polycomb Repressive Complex 1Protein AggregatesProto-Oncogene ProteinsRNA, Ribosomalpolycombself-renewalsenescencetissue regenerationtumor suppressor

Identifiers

PMID36167470
PMCPMC9575696
OpenAlexW4297387054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.