Evidence map›Paper›PMID 36167459›Full record

ReviewZhongguo fei ai za zhi = Chinese journal of lung cancer2022

[Progress of NRF2 Signaling Pathway in Promoting Proliferation 
of Non-small Cell Lung Cancer].

Yixuan Fang, Xinru Zou, Shuning Hu, Lili Ji

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yixuan FangDepartment of Pathological Anatomy, School of Medicine, Nantong University, Nantong 226001, China.
Xinru ZouDepartment of Pathological Anatomy, School of Medicine, Nantong University, Nantong 226001, China.
Shuning HuDepartment of Pathological Anatomy, School of Medicine, Nantong University, Nantong 226001, China.
Lili JiDepartment of Pathological Anatomy, School of Medicine, Nantong University, Nantong 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morbidity and mortality of lung cancer ranks among the top cancers in the world. Non-small cell lung cancer (NSCLC) is the main pathological type of lung cancer, with limited treatment options and poor prognosis. The nuclear factor E2-related factor 2 (NRF2) signaling pathway is highly mutated and activated in NSCLC, and promotes the malignant progression of lung cancer through various mechanisms. NRF2-targeted therapy will provide new treatment strategies for patients with NSCLC. This article will review the basic structure and response pathways of the NRF2 pathway, the mechanism of NRF2 regulating lung cancer cell proliferation, and the research and development progress of NRF2 inhibitors.
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Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsCell ProliferationGene Expression Regulation, NeoplasticHumansNF-E2-Related Factor 2Signal TransductionNF-E2-Related Factor 2Lung neoplasmsNRF2Proliferation

Identifiers

PMID36167459
PMCPMC9619341

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.