Evidence map›Paper›PMID 36167413›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Load-dependent inverted U-shaped connectivity of the default mode network in schizophrenia during a working-memory task: evidence from a replication functional MRI study.

Feiwen Wang, Chang Xi, Zhening Liu, Mengjie Deng, Wen Zhang, Hengyi Cao, Jie Yang, Lena Palaniyappan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Feiwen Wang *From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).
Chang Xi *From the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).
Zhening LiuFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).
Mengjie DengFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).
Wen ZhangFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).
Hengyi CaoFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).
Jie YangFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan) yang0826@csu.edu.cn.
Lena PalaniyappanFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the National Clinical Research Centre for Mental Disorders, Changsha, Hunan, China (Wang, Xi, Liu, Deng, Zhang, Yang); the Centre for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, New York (Cao); the Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York (Cao); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que. (Palaniyappan); the Department of Medical Biophysics, Western University, London, Ont. (Palaniyappan); the Robarts Research Institute, Western University, London, Ont. (Palaniyappan).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWorking-memory deficit is associated with aberrant degree distribution of the brain connectome in schizophrenia. However, the brain neural mechanism underlying the degree redistribution pattern in schizophrenia is still uncertain.

methodsWe examined the functional degree distribution of the connectome in 81 patients with schizophrenia and 77 healthy controls across different working-memory loads during an n-back task. We tested the associations between altered degree distribution and clinical symptoms, and we conducted functional connectivity analyses to investigate the neural mechanism underlying altered degree distribution. We repeated these analyses in a second independent data set of 96 participants. In the second data set, we employed machine-learning analysis to study whether the degree distribution pattern of one data set could be used to discriminate between patients with schizophrenia and controls in the other data set.

resultsPatients with schizophrenia showed decreased centrality in the dorsal posterior cingulate cortex (dPCC) for the "2-back versus 0-back" contrast compared to healthy controls. The dPCC centrality pattern across all working-memory loads was an inverted U shape, with a left shift of this pattern in patients with schizophrenia. This reduced centrality was correlated with the severity of delusions and related to reduced functional connectivity between the dPCC and the dorsal precuneus. We replicated these results with the second data set, and the machine-learning analyses achieved an accuracy level of 71%. LIMITATIONS: We used a limited n-back paradigm that precluded the examination of higher working-memory loads.

conclusionSchizophrenia is characterized by a load-dependent reduction of centrality in the dPCC, related to the severity of delusions. We suggest that restoring dPCC centrality in the presence of cognitive demands might have a therapeutic effect on persistent delusions in people with schizophrenia.

Indexed as

ConnectomeSchizophreniaDefault Mode NetworkHumansMagnetic Resonance ImagingMemory, Short-Term

Identifiers

PMID36167413
PMCPMC9524478

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