Evidence map›Paper›PMID 36167192›Full record

ArticleNeuropsychologia2022

Sleep duration moderates the associations between immune markers and corticolimbic function during stress in adolescents.

Jessica P Uy, Macrina Dieffenbach, Carrianne J Leschak, Naomi I Eisenberger, Andrew J Fuligni, Adriana Galván

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jessica P UyDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: jessicaphuong@ucla.edu.
Macrina DieffenbachDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Carrianne J LeschakDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Andrew J FuligniDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Adriana GalvánDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Pro-Social Behavior and Neural Development during AdolescenceR01HD093823 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EISENBERGER, NAOMI ILANA, FULIGNI, ANDREW J · 2018 to 2022
$2.8M
Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)T32HD091059 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mirella Dapretto, ANDREW J FULIGNI · 2018 to 2026
$1.7M
NICHD NIH HHS R01 HD093823NICHD NIH HHS T32 HD091059
6 · The paper itself

Abstract

Adolescence is characterized by biological changes in hormonal and circadian systems that, with concurrent psychosocial changes, result in increased sleep disturbances and stress sensitivity. Sleep disturbance has been associated with heightened stress sensitivity and elevated levels of inflammation in adults and adolescents, yet the neural correlates are unknown in adolescents. The current study investigated whether and how individual differences in peripheral immune markers (IL-6, TNF-α) related to neural response to stress in adolescents and whether these immune-brain associations were moderated by adolescents' sleep duration. Thirty-seven adolescents (14-15 years) who met quality control criteria for fMRI reported daily sleep duration for 7 days and performed a fMRI stressor task. A subsample of 23 adolescents additionally provided blood samples that were assayed for inflammatory markers using a multiplex assay. Results revealed that average sleep duration moderated associations between TNF-α and medial frontolimbic circuitry (amygdala, medial prefrontal cortex) during the stressor task such that, among adolescents who reported shorter sleep duration, higher levels of TNF-α were associated with greater deactivation in those regions during stress, which was associated with greater self-reported anxiety. These findings suggest that insufficient sleep duration coupled with greater levels of peripheral inflammation may promote a neural profile characterized by alterations in frontolimbic circuitry during stress, which can exacerbate sleep disturbances and/or peripheral inflammation.

Indexed as

Sleep DeprivationTumor Necrosis Factor-alphaAdolescentAdultBiomarkersHumansInflammationSleepBiomarkersTumor Necrosis Factor-alphaAdolescentsAmygdalaInflammationPrefrontal cortexSleepStress

Identifiers

PMID36167192
PMCPMC12050106
OpenAlexW4297182263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.