Evidence map›Paper›PMID 36166946›Full record

ArticlePsychiatry research2022

Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: A comprehensive assessment.

Alfonso Cabrera Lagunes, Adriana Díaz-Anzaldúa, Gustavo Rojas Andrade, Vanessa-Giselle Peschard, Adriana Arias Caballero, César Enrique Gaspar-Barba, Arlette Yunes Jimenez, Francisco Rafael De la Peña Olvera, Carlos Sabas Cruz Fuentes, Miriam Feria-Aranda and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Alfonso Cabrera LagunesComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Adriana Díaz-AnzaldúaDepartment of Genetics, Sub-division of Clinical Research, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Gustavo Rojas AndradeDepartment of Genetics, Sub-division of Clinical Research, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Vanessa-Giselle PeschardDepartment of Medicine, Division of Nephrology, University of California, San Francisco 941130, United States.
Adriana Arias CaballeroComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
César Enrique Gaspar-BarbaComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Arlette Yunes JimenezComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico; Eating Disorders Clinic, Instituto Prado S.C., Mexico City 11000, Mexico.
Francisco Rafael De la Peña OlveraAdolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico; Unit of Research Promotion, Direction of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Carlos Sabas Cruz FuentesDepartment of Genetics, Sub-division of Clinical Research, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Miriam Feria-ArandaComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico; Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Liz Sosa MoraComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico; Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Armando Pérez MolinaDepartment of Genetics, Sub-division of Clinical Research, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Diana Guizar SanchezDepartment of Physiology, Laboratory of Learning Sciences, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Lino Palacios-CruzComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico; Department of Clinical Epidemiology, Sub-division of Clinical Research, Division of Neurosciences, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico. Electronic address: palacioslino@gmail.com.
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz · MXInstituto de Salud del Estado de México · MXUniversidad Nacional Autónoma de México · MXUniversity of California, San Francisco · US

Funding

Academic Training Program in NephrologyT32DK007219 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 1986 to 2022
$7.3M
NRSA Training CoreTL1DK139565 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PHILIP A BEACHY, Chi-yuan Hsu · 2023 to 2026
$5.1M
NIDDK NIH HHS T32 DK007219NIDDK NIH HHS TL1 DK139565
6 · The paper itself

Abstract

This study aimed to evaluate markers of the CLOCK gene rs1801260 and rs4864548 in Mexican adolescents, addressing clinical and biological aspects previously associated with ADHD. 347 Mexican adolescents were assessed for mental disorders, metabolic disruption and related conditions, circadian preference, as well as genotyping for the CLOCK. We found a significant association between ADHD and the AA and AG genotypes of rs1801260. Also, we identified in the ADHD group that the total Triiodothyronine and total Thyroxine values were respectively 10 ng/dl units and 0.58 ug/dl units lower in females than in males. Previously reported common variations of the CLOCK gene have been associated with ADHD like the Rs1801260 polymorphism hereby we could consider it as risk factor, but genetic, biochemical and clinical studies in the Mexican population are entailed.

Indexed as

Attention Deficit Disorder with HyperactivityCLOCK ProteinsAdolescentFemaleGenotypeHumansMalePolymorphism, Single NucleotideCLOCK protein, humanCLOCK ProteinsAttention deficit disorder with hyperactivityCircadian rhythmGenotypeRisk factorsSingle nucleotide polymorphismThyroxineTriiodothyronine

Identifiers

PMID36166946
PMCPMC10824139
OpenAlexW4296276354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.