Evidence map›Paper›PMID 36166918›Full record

ArticleNeurobiology of aging2022

Functional connectivity to the premotor cortex maps onto longitudinal brain neurodegeneration in progressive apraxia of speech.

Irene Sintini, Joseph R Duffy, Heather M Clark, Rene L Utianski, Hugo Botha, Mary M Machulda, Matthew L Senjem, Edythe A Strand, Christopher G Schwarz, Val J Lowe and 3 more

Open access · greenAbstract read
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. An Update on Apraxia of Speech.Current neurology and neuroscience reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Irene SintiniDepartment of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: sintini.irene@mayo.edu.
Joseph R DuffyDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Heather M ClarkDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Rene L UtianskiDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Hugo BothaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Mary M MachuldaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Matthew L SenjemDepartment of Information Technology, Mayo Clinic, Rochester, MN, USA.
Edythe A StrandDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Speech & Hearing Sciences, University of Washington, Seattle, WA, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USWinnMed · US

Funding

Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2M
The neurobiology of two distinct types of progressive apraxia of speechR01DC014942 · NIDCD · MAYO CLINIC ROCHESTER · PI Keith A Josephs, Rene Lynn Utianski · 2017 to 2026
$4.9M
PIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7M
NIDCD NIH HHS R01 DC010367NIDCD NIH HHS R01 DC012519NIDCD NIH HHS R01 DC014942
6 · The paper itself

Abstract

Primary progressive apraxia of speech (PPAOS) is a neurodegenerative motor speech disorder affecting the ability to produce speech. If agrammatic aphasia is present, it can be referred to as the non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA). We investigated whether resting-state functional MRI (rs-fMRI) connectivity from disease "epicenters" correlated with longitudinal gray matter atrophy and hypometabolism in nfvPPA and PPAOS. Eighteen nfvPPA and 23 PPAOS patients underwent clinical assessment, structural MRI, rs-fMRI, and [

Indexed as

Aphasia, Primary ProgressiveApraxiasMotor CortexPrimary Progressive Nonfluent AphasiaAtrophyBrainFluorodeoxyglucose F18HumansMagnetic Resonance ImagingSpeechFluorodeoxyglucose F18AphasiaApraxia of speechFunctional connectivityLongitudinal neurodegenerationMultimodal imaging

Identifiers

PMID36166918
PMCPMC9613616
OpenAlexW4294190189

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.