Evidence map›Paper›PMID 36166832›Full record

ReviewBritish journal of pharmacology2023

Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling.

Reid H J Olsen, Justin G English

Abstract readReview
In one paragraph

Review in British journal of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Reid H J OlsenGPCR Pharmacology, Exscientia PLC, Oxford, UK.ORCID 0000-0003-4621-949X
Justin G EnglishDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0002-1161-8928

Funding

Directed Evolution of Cell-Type Specific On-Demand Signaling Control SystemsDP2GM146247 · NIGMS · UNIVERSITY OF UTAH · PI ENGLISH, JUSTIN G. · 2021 to 2024
$2.3M
NIGMS NIH HHS DP2 GM146247
6 · The paper itself

Abstract

Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in the human body, are plentiful and vary in utility, form and function. Their applications have continually expanded our understanding of this important protein class. Here, we briefly summarize a subset of this field with accelerating importance: transducer biosensors measuring receptor-coupling and selectivity, with an emphasis on sensors measuring receptor association and activation of heterotrimeric signalling complexes.

Indexed as

Biosensing TechniquesReceptors, G-Protein-CoupledGTP-Binding ProteinsHumansSignal TransductionGTP-Binding ProteinsReceptors, G-Protein-CoupledBERKYbiosensorBRETFRETfunctional selectivityGEMTAGPCRG protein coupled receptorsG proteinssignalling biasSPASMtransduceromeTRUPATH

Identifiers

PMID36166832
PMCPMC10511148

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.