Evidence map›Paper›PMID 36166682›Full record

Trial reportCirculation. Arrhythmia and electrophysiology2022

A Mechanistic Clinical Trial Using (

M Benjamin Shoemaker, Zachary T Yoneda, Diane M Crawford, Wendell S Akers, Travis Richardson, Jay A Montgomery, Sharon Phillips, Yu Shyr, Pablo Saavedra, Juan C Estrada and 6 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Arrhythmia and electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02710669 (Comparison of), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02710669 phase1 / phase2terminatednot on this map

Comparison of (R) and (S) Propafenone for Prevention of Atrial Fibrillation Induction

TypeinterventionalSponsorVanderbilt UniversityRan2016 to 2020Enrolled193ConditionsAtrial FibrillationArms(R)-propafenone, (S)-Propafenone, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Assaying sarcoplasmic reticulum CaBiophysics reports · 2024
    Article
  3. Article
  4. The Role ofCase reports in cardiology · 2023
    Article
  5. Targeting the RyR2 to Prevent Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

M Benjamin Shoemaker *Division of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0001-6824-7155
Zachary T Yoneda *Division of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0002-2055-732X
Diane M CrawfordDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.
Wendell S AkersDepartment of Pharmacology (W.S.A., B.C.K.), Vanderbilt University School of Medicine.
Travis RichardsonDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0002-9772-0308
Jay A MontgomeryDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0002-9950-940X
Sharon PhillipsDepartment of Biostatistics (S.P., Y.S.), Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-4230-4454
Yu ShyrDepartment of Biostatistics (S.P., Y.S.), Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-2086-9670
Pablo SaavedraDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.
Juan C EstradaDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.
Arvindh KanagasundramDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0001-8295-1528
Sharon T ShenDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0002-7959-300X
Gregory F MichaudDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.
George CrossleyDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.
Christopher R EllisDivision of Cardiology (M.B.S., Z.T.Y., D.M.C., T.R., J.A.M., P.S., J.C.E., A.K., S.T.S., G. F. M., G.C., C.R.E.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0002-7333-5720
Bjorn C KnollmannDivision of Clinical Pharmacology (B.C.K.), Department of Medicine, Vanderbilt University Medical Center.ORCID 0000-0003-4956-9735
Vanderbilt University Medical Center · USVanderbilt University · USLipscomb University · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
Toward a Mechanism-Based Approach to Treating Atrial FibrillationR01HL124935 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2015 to 2019
$2.8M
Atrial Fibrillation Susceptibility Due to Genetic Variation at Chromosome 4q25K23HL127704 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHOEMAKER, MOORE BENJAMIN · 2015 to 2019
$869k
NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K23 HL127704NHLBI NIH HHS R01 HL124935NHLBI NIH HHS R35 HL144980
6 · The paper itself

Abstract

backgroundExperimental data suggest ryanodine receptor-mediated intracellular calcium leak is a mechanism for atrial fibrillation (AF), but evidence in humans is still needed. Propafenone is composed of two enantiomers that are equally potent sodium-channel blockers; however,

methodsParticipants were randomized 4:4:1 to a one-time intravenous dose of

resultsA total of 193 participants were enrolled and 165 (85%) completed the study protocol (median age: 63 years, 58% male, 95% paroxysmal AF). Sustained AF and/or atrial flutter was induced in 60 participants (84.5%) receiving

conclusionsThere is no difference in AF inducibility between REGISTRATION: https://clinicaltrials.gov; Unique Identifier: NCT02710669.

Indexed as

Atrial FibrillationAtrial FlutterAnti-Arrhythmia AgentsCalciumFemaleHumansMaleMiddle AgedPropafenoneRyanodine Receptor Calcium Release ChannelSodiumAnti-Arrhythmia AgentsCalciumPropafenoneRyanodine Receptor Calcium Release ChannelSodiumablationatrial fibrillationcalcium leakclinical trialpropafenone

Identifiers

PMID36166682
PMCPMC9588733
OpenAlexW4297326433

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.