ArticleProceedings of the National Academy of Sciences of the United States of America2022
Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advancement in Human Face Prediction Using DNA.Genes · 2023Pooled it
- A Biomedical Researcher's Guide for Analyzing Short Tandem Repeat (STR) Genotypes of Human Cell Lines and in Vitro Tissue Samples Using Three Standard Authentication Algorithms.Current protocols · 2026Article
- Legitimacy of investigative forensic genetic genealogy under Art. 8 ECHR.Forensic science international. Synergy · 2025Article
- STR profiling in a cohort of Saudi patients with acute leukemia.Journal of Taibah University Medical Sciences · 2025Article
- Principles and Policy Recommendations for Comprehensive Genetic Data Governance.Proceedings of the AAAI/ACM Conference on AI, Ethics, and Society · 2025Article
- Article
- Solving the Arizona search problem by imputation.iScience · 2024Article
- Microsatellites used in forensics are in regions enriched for trait-associated variants.iScience · 2023Article
- Microsatellites used in forensics are located in regions unusually rich in trait-associated variants.bioRxiv : the preprint server for biology · 2023Article
- Gattaca as a lens on contemporary genetics: marking 25 years into the film's "not-too-distant" future.Genetics · 2022Article
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Authors and funding
11 authors.
Funding
Abstract
A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in putative gene deserts to avoid forensic profiles revealing protected medical information. We revisit that assumption, investigating whether forensic genetic profiles reveal information about gene-expression variation or potential medical information. We find six significant correlations (false discovery rate = 0.23) between the forensic STRs and the expression levels of neighboring genes in lymphoblastoid cell lines. We explore possible mechanisms for these associations, showing evidence compatible with forensic STRs causing expression variation or being in linkage disequilibrium with a causal locus in three cases and weaker or potentially spurious associations in the other three cases. Together, these results suggest that forensic genetic loci may reveal expression levels and, perhaps, medical information.
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