Evidence map›Paper›PMID 36166476›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Elastic properties and shape of the Piezo dome underlying its mechanosensory function.

Christoph A Haselwandter, Yusong R Guo, Ziao Fu, Roderick MacKinnon

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Yoda molecules agonize PIEZO2.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Piezo2 tension sensitivity and its modulation by alternative splicing.bioRxiv : the preprint server for biology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. PIEZO channels as multimodal mechanotransducers.Biochemical Society transactions · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Structure of the flotillin complex in a native membrane environment.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Christoph A HaselwandterDepartment of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089.ORCID 0000-0002-5012-5640
Yusong R GuoLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.
Ziao FuLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.
Rockefeller University · USUniversity of Southern California · US

Funding

Voltage-Dependent Ion Channel GatingR01GM043949 · NIGMS · ROCKEFELLER UNIVERSITY · PI MACKINNON, RODERICK · 1990 to 2024
$10.1M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM043949
6 · The paper itself

Abstract

We show in the companion paper that the free membrane shape of lipid bilayer vesicles containing the mechanosensitive ion channel Piezo can be predicted, with no free parameters, from membrane elasticity theory together with measurements of the protein geometry and vesicle size [C. A. Haselwandter, Y. R. Guo, Z. Fu, R. MacKinnon,

Indexed as

Ion ChannelsLipid BilayersCell MembraneElasticityMechanical PhenomenaMechanotransduction, CellularIon ChannelsLipid Bilayersmechanical gatingmechanosensationmembrane mechanicsPiezo ion channels

Identifiers

PMID36166476
PMCPMC9546593
OpenAlexW4297258017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.