Evidence map›Paper›PMID 36166461›Full record

ArticlePloS one2022

Curcumin-loaded nanocomplexes ameliorate the severity of nonalcoholic steatohepatitis in hamsters infected with Opisthorchis viverrini.

Chutima Sitthirach, Lakhanawan Charoensuk, Chawalit Pairojkul, Apisit Chaidee, Kitti Intuyod, Thatsanapong Pongking, Phonpilas Thongpon, Chanakan Jantawong, Nuttanan Hongsrichan, Sakda Waraasawapati and 2 more

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In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chutima SitthirachDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Lakhanawan CharoensukCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Chawalit PairojkulCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Apisit ChaideeDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID 0000-0001-6495-0951
Kitti IntuyodCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Thatsanapong PongkingCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Phonpilas ThongponDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Chanakan JantawongCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Nuttanan HongsrichanDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Sakda WaraasawapatiCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Manachai YingklangCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Somchai PinlaorDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID 0000-0002-8187-7247

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComorbidity of Opisthorchis viverrini (OV) infection and nonalcoholic fatty-liver disease (NAFLD) enhances NAFLD progression to nonalcoholic steatohepatitis (NASH) by promoting severe liver inflammation and fibrosis. Here, we investigated the effect of supplementation with curcumin-loaded nanocomplexes (CNCs) on the severity of NASH in hamsters. METHODOLOGY: Hamsters were placed in experimental groups as follows: fed standard chow diet (normal control, NC); fed only high-fat and high-fructose (HFF) diet; O. viverrini-infected and fed HFF diet (HFFOV); group fed with blank nanocomplexes (HFFOV+BNCs); groups fed different doses of CNCs (25, 50 and 100 mg/kg body weight: HFFOV+CNCs25; HFFOV+CNCs50; HFFOV+CNCs100, respectively) and a group given native curcumin (HFFOV+CUR). All treatment were for three months.

resultsThe HFF group revealed NAFLD as evidenced by hepatic fat accumulation, ballooning, mild inflammation and little or no fibrosis. These changes were more obvious in the HFFOV group, indicating development of NASH. In contrast, in the HFFOV+CNCs50 group, histopathological features indicated that hepatic fat accumulation, cell ballooning, cell inflammation and fibrosis were lower than in other treatment groups. Relevantly, the expression of lipid-uptake genes, including fatty-acid uptake (cluster of differentiation 36), was reduced, which was associated with the lowering of alanine aminotransferase, total cholesterol and triglyceride (TG) levels. Reduced expression of an inflammation marker (high-mobility group box protein 1) and a fibrosis marker (alpha smooth-muscle actin) were also observed in the HFFOV+CNCs50 group.

conclusionCNCs treatment attenuates the severity of NASH by decreasing hepatic steatosis, inflammation, and fibrosis as well as TG synthesis. CNCs mitigate the severity of NASH in this preclinical study, which indicates promise for future use in patients.

Indexed as

CurcuminNon-alcoholic Fatty Liver DiseaseOpisthorchiasisOpisthorchisActinsAlanine TransaminaseAnimalsCholesterolCricetinaeDiet, High-FatDisease Models, AnimalFructoseHumansInflammationLipidsLiverActinsAlanine TransaminaseCholesterolCurcuminFructoseLipidsTriglycerides

Identifiers

PMID36166461
PMCPMC9514634

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.