Evidence map›Paper›PMID 36166414›Full record

ArticlePloS one2022

Laboratory and field evaluation of the STANDARD Q and Panbio™ SARS-CoV-2 antigen rapid test in Namibia using nasopharyngeal samples.

Iyaloo Konstantinus, Douglas Chiwara, Emmy-Else Ndevaetela, Victoria Ndarukwa-Phiri, Nathalia Garus-Oas, Ndahafa Frans, Pentikainen Ndumbu, Andreas Shiningavamwe, Gerhard van Rooyen, Ferlin Schiceya and 6 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Article
  3. The Performance of a Rapid Coronavirus Disease 2019 Antigen Test in Rural Gabon.The American journal of tropical medicine and hygiene · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Iyaloo KonstantinusDepartment of Research, Namibia Institute of Pathology, Windhoek, Namibia.ORCID 0000-0001-9566-6654
Douglas ChiwaraDepartment of Quality Assurance, Namibia Institute of Pathology, Windhoek, Namibia.
Emmy-Else NdevaetelaDivision of Epidemiology, Ministry of Health and Social Services, Windhoek, Namibia.
Victoria Ndarukwa-PhiriDivision of Epidemiology, Ministry of Health and Social Services, Windhoek, Namibia.
Nathalia Garus-OasDepartment of Molecular Diagnostics, Namibia Institute of Pathology, Windhoek, Namibia.
Ndahafa FransDepartment of Molecular Diagnostics, Namibia Institute of Pathology, Windhoek, Namibia.
Pentikainen NdumbuDepartment of Molecular Diagnostics, Namibia Institute of Pathology, Windhoek, Namibia.
Andreas ShiningavamweDepartment of Molecular Diagnostics, Namibia Institute of Pathology, Windhoek, Namibia.
Gerhard van RooyenDepartment of Molecular Diagnostics, Namibia Institute of Pathology, Windhoek, Namibia.
Ferlin SchiceyaDivision of Case Management, Ministry of Health and Social Services, Windhoek, Namibia.ORCID 0000-0002-9449-1407
Lindile HlahlaDivision of Case Management, Ministry of Health and Social Services, Windhoek, Namibia.
Pendapala NamundjeboDivision of Epidemiology, Ministry of Health and Social Services, Windhoek, Namibia.
Ifeoma Ndozi-OkiaDivision of Epidemiology, Ministry of Health and Social Services, Windhoek, Namibia.
Francis ChikuseDivision of Epidemiology, Ministry of Health and Social Services, Windhoek, Namibia.
Sirak Hailu BantiewaluWorld Health Organization Country Office, Windhoek, Namibia.
Kapena TjombondeDepartment of Research, Namibia Institute of Pathology, Windhoek, Namibia.
Namibia Institute of Pathology · NAMinistry of Health and Social Services · NA

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundAs new SARS-CoV-2 variants of concern emerge, there is a need to scale up testing to minimize transmission of the Coronavirus disease 2019 (COVID-19). Many countries especially those in the developing world continue to struggle with scaling up reverse transcriptase polymerase reaction (RT-PCR) to detect SARS-CoV-2 due to scarcity of resources. Alternatives such as antigen rapid diagnostics tests (Ag-RDTs) may provide a solution to enable countries scale up testing.

methodsIn this study, we evaluated the Panbio™ and STANDARD Q Ag-RDTs in the laboratory using 80 COVID-19 RT-PCR confirmed and 80 negative nasopharyngeal swabs. The STANDARD Q was further evaluated in the field on 112 symptomatic and 61 asymptomatic participants.

resultsFor the laboratory evaluation, both tests had a sensitivity above 80% (Panbio™ = 86% vs STANDARD Q = 88%). The specificity of the Panbio™ was 100%, while that of the STANDARD Q was 99%. When evaluated in the field, the STANDARD Q maintained a high specificity of 99%, however the sensitivity was reduced to 56%.

conclusionUsing Ag-RDTs in low resource settings will be helpful in scaling-up SARS-CoV-2 testing, however, negative results should be confirmed by RT-PCR where possible to rule out COVID-19 infection.

Indexed as

COVID-19SARS-CoV-2Antigens, ViralCOVID-19 TestingHumansNamibiaRNA-Directed DNA PolymeraseSensitivity and SpecificityAntigens, ViralRNA-Directed DNA Polymerase

Identifiers

PMID36166414
PMCPMC9514621
OpenAlexW4297254373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.