Evidence map›Paper›PMID 36166181›Full record

ArticleScience China. Life sciences2022

PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure.

Guoqing Tang, Chengxin Ma, Liangkui Li, Shaoyan Zhang, Fengsheng Li, Jin Wu, Yesheng Yin, Qing Zhu, Yan Liang, Ru Wang and 5 more

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. PITPNC1 Suppress CD8Journal of translational medicine · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Guoqing Tang *Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Chengxin Ma *Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Liangkui LiState Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Shaoyan ZhangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Fengsheng LiShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Jin WuShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Yesheng YinShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Qing ZhuShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Yan LiangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Ru WangSchool of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
He HuangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Tong-Jin ZhaoShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Hongyuan YangSchool of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW, 2052, Australia.
Peng LiShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
Feng-Jung ChenShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. derrick_chen@fudan.edu.cn.
Zhongshan Hospital · CNFudan University · CNShangHai JiAi Genetics & IVF Institute · CNThe First Affiliated Hospital, Sun Yat-sen University · CNCenter for Life Sciences · CNShanghai University of Sport · CNSun Yat-sen University · CNUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1

Indexed as

Adipose Tissue, BrownThermogenesisAnimalsHomeostasisMiceMice, KnockoutMitochondriaacute cold exposurelipid homeostasisPITPNC1thermogenesisβ-oxidation

Identifiers

PMID36166181
OpenAlexW4297250079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.