Evidence map›Paper›PMID 36166113›Full record

ArticleJournal of neuro-oncology2022

Stereotactic radiosurgery for Koos grade IV vestibular schwannoma in young patients: a multi-institutional study.

Chloe Dumot, Stylianos Pikis, Georgios Mantziaris, Zhiyuan Xu, Rithika Kormath Anand, Ahmed M Nabeel, Darrah Sheehan, Kimball Sheehan, Wael A Reda, Sameh R Tawadros and 28 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Failure of gamma knife radiosurgery for sporadic vestibular schwannomas: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 15 institutions in 7 countries.

Chloe DumotDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Stylianos PikisDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Georgios MantziarisDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Zhiyuan XuDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Rithika Kormath AnandDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Ahmed M NabeelGamma Knife Center Cairo, Nasser Institute Cairo, Cairo, Egypt.
Darrah SheehanDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Kimball SheehanDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Wael A RedaGamma Knife Center Cairo, Nasser Institute Cairo, Cairo, Egypt.
Sameh R TawadrosGamma Knife Center Cairo, Nasser Institute Cairo, Cairo, Egypt.
Khaled Abdel KarimGamma Knife Center Cairo, Nasser Institute Cairo, Cairo, Egypt.
Amr M N El-ShehabyGamma Knife Center Cairo, Nasser Institute Cairo, Cairo, Egypt.
Reem M Emad EldinGamma Knife Center Cairo, Nasser Institute Cairo, Cairo, Egypt.
Selcuk PekerDepartment of Neurosurgery, Koc University School of Medicine, Istanbul, Turkey.
Yavuz SamanciDepartment of Neurosurgery, Koc University School of Medicine, Istanbul, Turkey.
Tehila Kaisman-ElbazRose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Herwin SpeckterDepartment of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo, Dominican Republic.
Wenceslao HernándezDepartment of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo, Dominican Republic.
Julio IsidorDepartment of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo, Dominican Republic.
Manjul TripathiDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Renu MadanDepartment of Radiation Therapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Brad E ZachariaDepartment of Neurosurgery, Penn State Health-Hershey Medical Center, Hershey, PA, USA.
Lekhaj C DaggubatiDepartment of Neurosurgery, Penn State Health-Hershey Medical Center, Hershey, PA, USA.
Nuria Martínez MorenoDepartment of Radiosurgery, Rúber International Hospital, Madrid, Spain.
Roberto Martínez ÁlvarezDepartment of Radiosurgery, Rúber International Hospital, Madrid, Spain.
Anne-Marie LangloisDivision of Neurosurgery, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada.
David MathieuDivision of Neurosurgery, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada.
Christopher P DeibertDepartment of Neurological Surgery, Emory University, Atlanta, Georgia.
Vivek R SudhakarDepartment of Neurosurgery, West Virginia University, Morgantown, WV, USA.
Christopher P CifarelliDepartment of Neurosurgery, West Virginia University, Morgantown, WV, USA.
Denisse Arteaga IcazaDepartment of Neurosurgery, West Virginia University, Morgantown, WV, USA.
Daniel T CifarelliDepartment of Neurosurgery, West Virginia University, Morgantown, WV, USA.
Zhishuo WeiDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Ajay NiranjanDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Gene H BarnettRose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
L Dade LunsfordDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Greg N BowdenDepartment of Neurosurgery, University of Alberta, Edmonton, AB, Canada.
Jason P SheehanDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA. jsheehan@virginia.edu.
Neurological Surgery · USUniversity of Virginia Health System · USWest Virginia University · USUniversity of Pittsburgh · USAin Shams University · EGHospital Ruber Internacional · ESKoç University · TRNasser Institute hospital · EGPenn State Milton S. Hershey Medical Center · USPost Graduate Institute of Medical Education and Research · INThe Neurological Institute · USUniversité de Sherbrooke · CABenha University · EGCairo University · EGUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSurgery is the treatment of choice for large vestibular schwannomas (VS). Stereotactic radiosurgery (SRS) has been suggested as an alternative to resection in selected patients. However, the safety and efficacy of SRS in Koos grade IV patients ≤ 45 years old has not been evaluated. The aim of this study is to describe the clinical and radiological outcomes of Koos grade IV in young patient managed with a single-session SRS.

methodsThis retrospective, multicenter analysis included SRS-treated patients, ≤ 45 years old presenting with non-life threatening or incapacitating symptoms due to a Koos Grade IV VS and with follow-up ≥ 12 months. Tumor control and neurological outcomes were evaluated.

results176 patients [median age of 36.0 (IQR 9) and median tumor volume of 9.3 cm

conclusionSingle-session SRS is a safe and effective alternative to surgical resection in selected patients ≤ 45 years old particularly those with medical co-morbidities and those who decline resection. Longer term follow up is warranted.

Indexed as

Neuroma, AcousticRadiosurgeryFollow-Up StudiesHearingHumansMiddle AgedRetrospective StudiesTreatment OutcomeKoos grade IVStereotactic radiosurgeryVestibular schwannomaYoung age

Identifiers

PMID36166113
OpenAlexW4297248821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.