ArticleBritish journal of haematology2022
Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients.
Article in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- New perspectives on the induction and acceleration of immune-associated thrombosis by PF4 and VWF.Frontiers in immunology · 2023Review
- Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients.British journal of haematology · 2022Article
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Authors and funding
17 authors at 8 institutions in 2 countries.
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Abstract
Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes, suggesting a role for alternative factors, like platelets. Here, we investigated platelet factor 4 (PF4) in a large cohort of patients with VWD. PF4 levels were lower in type 2B and current bleeding phenotype was significantly associated with higher PF4 levels, particularly in type 1 VWD. Based on our findings we speculate that platelet degranulation and cargo release may play a role across VWD subtypes.
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