Evidence map›Paper›PMID 36165792›Full record

ArticleRadiology2023

Abdominal CT Body Composition Thresholds Using Automated AI Tools for Predicting 10-year Adverse Outcomes.

Matthew H Lee, Ryan Zea, John W Garrett, Peter M Graffy, Ronald M Summers, Perry J Pickhardt

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  11. Improved muscle and fat segmentation for body composition measures on quantitative CT.International journal of computer assisted radiology and surgery · 2025
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  15. A unified approach to medical image segmentation by leveraging mixed supervision and self and transfer learning (MIST).Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew H LeeFrom the Departments of Radiology (M.H.L., R.Z., J.W.G., P.M.G., P.J.P.) and Medical Physics (J.W.G.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792; and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (R.M.S.).ORCID 0000-0001-8500-0306
Ryan ZeaFrom the Departments of Radiology (M.H.L., R.Z., J.W.G., P.M.G., P.J.P.) and Medical Physics (J.W.G.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792; and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (R.M.S.).ORCID 0000-0002-0745-6663
John W GarrettFrom the Departments of Radiology (M.H.L., R.Z., J.W.G., P.M.G., P.J.P.) and Medical Physics (J.W.G.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792; and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (R.M.S.).ORCID 0000-0002-8152-736X
Peter M GraffyFrom the Departments of Radiology (M.H.L., R.Z., J.W.G., P.M.G., P.J.P.) and Medical Physics (J.W.G.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792; and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (R.M.S.).ORCID 0000-0002-2156-7175
Ronald M SummersFrom the Departments of Radiology (M.H.L., R.Z., J.W.G., P.M.G., P.J.P.) and Medical Physics (J.W.G.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792; and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (R.M.S.).ORCID 0000-0001-8081-7376
Perry J PickhardtFrom the Departments of Radiology (M.H.L., R.Z., J.W.G., P.M.G., P.J.P.) and Medical Physics (J.W.G.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792; and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (R.M.S.).ORCID 0000-0002-5534-8202
National Institutes of Health Clinical Center · USUniversity of Wisconsin–Madison · US

Funding

Can machines be trusted? Robustification of deep learning for medical imagingR01LM013151 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI GARRETT, JOHN WILLIAM, MCMILLAN, ALAN BLAIR · 2020 to 2023
$1.3M
Computer Aided Detection for CT ColonographyZIACL040003 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
Computer Aided Detection for Radiologic ImagesZIACL040004 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
NLM NIH HHS R01 LM013151
6 · The paper itself

Abstract

Background CT-based body composition measures derived from fully automated artificial intelligence tools are promising for opportunistic screening. However, body composition thresholds associated with adverse clinical outcomes are lacking. Purpose To determine population and sex-specific thresholds for muscle, abdominal fat, and abdominal aortic calcium measures at abdominal CT for predicting risk of death, adverse cardiovascular events, and fragility fractures. Materials and Methods In this retrospective single-center study, fully automated algorithms for quantifying skeletal muscle (L3 level), abdominal fat (L3 level), and abdominal aortic calcium were applied to noncontrast abdominal CT scans from asymptomatic adults screened from 2004 to 2016. Longitudinal follow-up documented subsequent death, adverse cardiovascular events (myocardial infarction, cerebrovascular event, and heart failure), and fragility fractures. Receiver operating characteristic (ROC) curve analysis was performed to derive thresholds for body composition measures to achieve optimal ROC curve performance and high specificity (90%) for 10-year risks. Results A total of 9223 asymptomatic adults (mean age, 57 years ± 7 [SD]; 5152 women and 4071 men) were evaluated (median follow-up, 9 years). Muscle attenuation and aortic calcium had the highest diagnostic performance for predicting death, with areas under the ROC curve of 0.76 for men (95% CI: 0.72, 0.79) and 0.72 for women (95% CI: 0.69, 0.76) for muscle attenuation. Sex-specific thresholds were higher in men than women (

Indexed as

Cardiovascular DiseasesFractures, BoneAbdominal MusclesAdultArtificial IntelligenceBody CompositionCalciumFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedCalcium

Identifiers

PMID36165792
PMCPMC9885340
OpenAlexW4297263781

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.