Evidence map›Paper›PMID 36165790›Full record

ArticleRadiology2023

A Pilot Study to Assess the Performance of Phase-Sensitive Breast Tomosynthesis.

Laurie L Fajardo, Stephen L Hillis, Bin Zheng, Molly Donovan Wong, Muhammad U Ghani, Farid H Omoumi, Yuhua Li, Peter Jenkins, Michael E Peterson, Xizeng Wu and 1 more

Abstract read
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Laurie L FajardoFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0001-6853-4832
Stephen L HillisFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0002-4886-8584
Bin ZhengFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0002-7682-6648
Molly Donovan WongFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0003-4790-0586
Muhammad U GhaniFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0002-3308-0989
Farid H OmoumiFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0003-1956-0879
Yuhua LiFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0002-4626-658X
Peter JenkinsFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).
Michael E PetersonFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0003-3869-504X
Xizeng WuFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0002-0295-9587
Hong LiuFrom the Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah (L.L.F., P.J., M.E.P.); Departments of Radiology and Biostatistics, University of Iowa, Iowa City, Iowa (S.L.H.); Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 (B.Z., M.D.W., M.U.G., F.H.O., Y.L., H.L.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (X.W.).ORCID 0000-0002-0896-8409

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Clinical Translation of High Energy Phase-Sensitive X-ray Breast TomosynthesisR01CA193378 · NCI · UNIVERSITY OF OKLAHOMA · PI FAJARDO, LAURIE L, JING, ZHENXUE · 2015 to 2019
$3.0M
Generalized Obuchowski-Rockette Methodology for Analysis of Radiologic Diagnostic Imaging StudiesR01EB025174 · NIBIB · UNIVERSITY OF IOWA · PI HILLIS, STEPHEN LAWRENCE · 2018 to 2021
$2.0M
A Novel Low Dose and Accurate Phase Sensitive Breast Tomosynthesis (PBT) System based on Photon Counting Detector Technology for Cancer ImagingF32CA250300 · NCI · UNIVERSITY OF OKLAHOMA · PI GHANI, MUHAMMAD U · 2020 to 2021
$116k
NCATS NIH HHS UL1 TR002538NCI NIH HHS F32 CA250300NCI NIH HHS R01 CA193378NIBIB NIH HHS R01 EB025174
6 · The paper itself

Abstract

Background A new modality, phase-sensitive breast tomosynthesis (PBT), may have similar diagnostic performance to conventional breast tomosynthesis but with a reduced radiation dose. Purpose To perform a pilot study of the performance of a novel PBT system compared with conventional digital breast tomosynthesis (DBT) in patients undergoing additional diagnostic imaging workup for breast lesions. Materials and Methods In a prospective study from June 2020 to March 2021, participants with suspicious breast lesions detected at screening DBT or MRI were recruited for additional PBT imaging before additional diagnostic workup or biopsy. In this pilot study, nine radiologists independently evaluated image quality and assessed the likelihood of lesion malignancy by retrospectively evaluating DBT and PBT images in two separate reading sessions. Image quality was rated subjectively using a Likert scale from 1 to 5. Areas under the receiver operating characteristic curve (AUCs) were used to compare the lesion classification (malignant vs benign) performance of the radiologists. Results Images in 50 patients (mean age, 56 years ± 12 [SD]; 49 women) with 52 evaluable lesions (28 malignant) were assessed. For image appearance and general feature visibility, DBT images had a higher total mean image quality score (3.8) than PBT images (2.9), with

Indexed as

BreastBreast NeoplasmsFemaleHumansMammographyMiddle AgedPilot ProjectsProspective StudiesRetrospective Studies

Identifiers

PMID36165790
PMCPMC9885338

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.