Evidence map›Paper›PMID 36165780›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2022

Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology.

Michael Feiss, Ryland Young, Jolene Ramsey, Sankar Adhya, Costa Georgopoulos, Roger W Hendrix, Graham F Hatfull, Eddie B Gilcrease, Sherwood R Casjens

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Michael FeissDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowagrid.214572.7, Iowa City, Iowa, USA.ORCID 0000-0001-6330-3226
Ryland YoungCenter for Phage Technology, Texas A&M AgriLife Research, College Station, Texas, USA.
Jolene RamseyCenter for Phage Technology, Texas A&M AgriLife Research, College Station, Texas, USA.ORCID 0000-0002-3774-5896
Sankar AdhyaLaboratory of Molecular Biology, Center for Cancer Research, The National Cancer Institutegrid.48336.3a, Bethesda, Maryland, USA.
Costa GeorgopoulosDepartment of Biochemistry, University of Utahgrid.223827.e School of Medicine, Salt Lake City, Utah, USA.
Roger W HendrixDepartment of Biological Sciences, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Graham F HatfullDepartment of Biological Sciences, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6705-6821
Eddie B GilcreaseDepartment of Civil and Environmental Engineering, University of Utahgrid.223827.e, Salt Lake City, Utah, USA.
Sherwood R CasjensDivision of Microbiology and Immunology, Pathology Department, University of Utahgrid.223827.e School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0002-1213-7130
University of Utah · USTexas A&M University · USUniversity of Pittsburgh · USNational Cancer Institute · USUniversity of Iowa · US

Funding

Bacteriophage diversity, dynamics, function, and exploitationR35GM131729 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Graham F. Hatfull · 2019 to 2026
$3.6M
Phage LysisR35GM136396 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI YOUNG, RYLAND FLETCHER · 2020 to 2024
$1.9M
DNA packaging and delivery by dsDNA virusesR01GM114817 · NIGMS · UNIVERSITY OF UTAH · PI CASJENS, SHERWOOD R. · 2014 to 2017
$1.5M
NIGMS NIH HHS R01 GM114817NIGMS NIH HHS R35 GM131729NIGMS NIH HHS R35 GM136396NIH HHS NIH R01 GM114817
6 · The paper itself

Abstract

Laboratory-generated hybrids between phage λ and related phages played a seminal role in establishment of the λ model system, which, in turn, served to develop many of the foundational concepts of molecular biology, including gene structure and control. Important λ hybrids with phages 21 and 434 were the earliest of such phages. To understand the biology of these hybrids in full detail, we determined the complete genome sequences of phages 21 and 434. Although both genomes are canonical members of the λ-like phage family, they both carry unsuspected bacterial virulence gene types not previously described in this group of phages. In addition, we determined the sequences of the hybrid phages λ

Indexed as

Bacteriophage lambdaHybrid VigorMolecular Biologybacteriophagehybrid phagelysogenyphagephage 21phage 434phage geneticsphage lambdatemperate phage

Identifiers

PMID36165780
PMCPMC9799177
OpenAlexW4297261356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.