ArticleEuropean journal of endocrinology2022
Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study.
Article in European journal of endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature.Pituitary · 2025Pooled it
- Anxiety, depression and acromegaly: a systematic review.Journal of endocrinological investigation · 2025Pooled it
- MPOWERED Trial Open-Label Extension: Long-term Efficacy and Safety Data for Oral Octreotide Capsules in Acromegaly.The Journal of clinical endocrinology and metabolism · 2023Trial
- Acromegaly and cardiovascular disease: mechanisms, clinical impact, and evolving management.Endocrine reviews · 2026Review
- The acromegaly patient experience: burden of treatment and quality of life.The Journal of clinical endocrinology and metabolism · 2026Review
- Recent progress in the understanding of psychological complications of acromegaly: toward a longitudinal clinical phenotype.Pituitary · 2026Review
- Article
- Acromegaly and Morris Syndrome: Description of a Clinical CaseEndocrine, metabolic & immune disorders drug targets · 2026Article
- Psychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates.Pituitary · 2025Article
- Metabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross-Sectional Study in China.CNS neuroscience & therapeutics · 2025Article
- Patient perspectives on acromegaly disease burden: insights from a community meeting.Frontiers in endocrinology · 2025Article
- Impact of growth hormone-secreting pituitary adenoma on limbic system and its correlation with cognitive impairment.Heliyon · 2024Article
- Exploring potential influencing factors of inadherence to specialist aftercare and long-term medication in patients with acromegaly.Pituitary · 2024Article
- Quality of life in patients with acromegaly: a scoping review.Orphanet journal of rare diseases · 2024Article
- Cognition and psychological wellbeing in hypopituitary patients.Reviews in endocrine & metabolic disorders · 2024Review
- Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats.Psychopharmacology · 2024Article
- Pituitary neuroendocrine tumor: A neuropsychological comparison with intra-axial tumor.Annals of clinical and translational neurology · 2024Article
- Acromegalic Rat Model Presented Cognitive Impairments and Tau Hyperphosphorylation in the Hippocampus.Neuroendocrinology · 2024Article
- Erectile function and androgen and estrogen beta receptor gene polymorphisms in acromegalic men.Journal of endocrinological investigation · 2024Article
- Cognitive Dysfunction, an Increasingly Valued Long-Term Impairment in Acromegaly.Journal of clinical medicine · 2023Review
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Acromegaly is associated with somatic disfigurements which impair self-perception of well-being and quality of life. Nowadays, limited data are available on the interplay between hormonal excess and psychological discomfort. The study aimed at investigating the psychological profile, sleep quality, sexual function, cognitive functions, and quality of life in patients with acromegaly. Methods: In 223 acromegaly patients from 5 referral centres, global psychological profile, sleep quality, sexual function, cognitive function, and quality of life were investigated. Results: Depression was found in ~30% of patients, and anxiety in two-thirds, together with severe discomfort in body image mainly in women. Obstructive sleep apnoea syndrome risk and sleep disorders were found in >50% of patients and daily sleepiness in ~20%. Sexual dysfunction was reported in most of the patients, with the most severe impairment in women. Cognitive functions were compromised in ~10% of cases. Disease duration and patient's age and gender were the main determinants of these psychopathological conditions. Depression (P = 0.047), somatic-affective mood lowering (P = 0.021), state (P < 0.001) and trait (P = 0.013) anxiety, and body image distortion in body uneasiness test A (P < 0.001) and B (P = 0.006) were significantly worsened in patients <45 years and slightly worsened in those with disease duration less than 2 years. Male (P < 0.001) and female (P < 0.001) sexual function scores were significantly worsened in patients aged >64 years and slightly worsened in those with disease duration for more than 10 years, particularly in presence of cardiometabolic and respiratory complications. Cognitive symptoms were slightly worsened in older patients and in those with long disease duration. Conclusions: Acromegaly is associated with a relevant impairment of psychological profile persisting despite remission and long-term medical treatment.
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