Evidence map›Paper›PMID 36165630›Full record

ArticleAntimicrobial agents and chemotherapy2022

Reduced Ceftaroline Susceptibility among Invasive MRSA Infections in Children: a Clinical and Genomic Investigation.

J Chase McNeil, Lauren M Sommer, Jesus G Vallejo, Kristina G Hulten, Sheldon L Kaplan, Anthony R Flores

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. BeyondAntimicrobial agents and chemotherapy · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J Chase McNeilDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicinegrid.39382.33 and Texas Children's Hospital, Houston, Texas, USA.ORCID 0000-0002-0232-7491
Lauren M SommerDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicinegrid.39382.33 and Texas Children's Hospital, Houston, Texas, USA.
Jesus G VallejoDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicinegrid.39382.33 and Texas Children's Hospital, Houston, Texas, USA.
Kristina G HultenDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicinegrid.39382.33 and Texas Children's Hospital, Houston, Texas, USA.
Sheldon L KaplanDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicinegrid.39382.33 and Texas Children's Hospital, Houston, Texas, USA.
Anthony R FloresDivision of Infectious Diseases, Department of Pediatrics, McGovern Medical School, UTHealth Houston, Children's Memorial Hermann Hospital, Houston, Texas, USA.ORCID 0000-0002-6402-4269

Funding

Impact of a novel emm-enn gene fusion event on epidemic behavior of group A streptococcusR21AI142126 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FLORES, ANTHONY RICHARD, SHELBURNE, SAMUEL A · 2019 to 2020
$447k
Evolution and pathogenesis of serotype V group B Streptococcus in humansR21AI153663 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FLORES, ANTHONY RICHARD · 2021 to 2022
$429k
AHRQ HHS R01 HS026896NIAID NIH HHS R21 AI142126NIAID NIH HHS R21 AI153663
6 · The paper itself

Abstract

Ceftaroline represents an attractive therapy option for methicillin-resistant Staphylococcus aureus (MRSA). Little data is available, however, regarding the frequency of reduced susceptibility (RS) to ceftaroline among pediatric MRSA infections. We screened invasive MRSA isolates at a tertiary children's hospital for ceftaroline RS. Ceftaroline RS occurred in 2.9% of isolates and only among health care associated infections. Ceftaroline RS isolates were more often clindamycin-resistant. Sequencing data indicated the predominance of the CC5 lineage among ceftaroline RS isolates.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsCeftarolineCephalosporinsChildClindamycinGenomicsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsCeftarolineCephalosporinsClindamycinceftarolinehealth care associatedinvasivemecRMRSApediatricresistance

Identifiers

PMID36165630
PMCPMC9578395

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.