ArticleJournal of immunology (Baltimore, Md. : 1950)2022
Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.
Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Review
- CXCL10/CXCR3 axis facilitates the M2 polarization of macrophages in colorectal cancer via activating RAF.Discover oncology · 2025Article
- Context-specific anti-inflammatory roles of type III interferon signaling in the lung in nonviral injuries.Physiological reports · 2024Article
- Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex.Human genomics · 2024Article
- Anti-inflammatory roles of type I interferon signaling in the lung.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Review
- A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage againstAntibiotics (Basel, Switzerland) · 2023Article
- Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review.Frontiers in immunology · 2023Review
- Article
- Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis.EMBO molecular medicine · 2022Article
- Bacterial co-infection and secondary infection in critically ill patients with acute respiratory failure of coronavirus disease 2019.Tzu chi medical journalArticle
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
Postviral bacterial infections are a major health care challenge in coronavirus infections, including COVID-19; however, the coronavirus-specific mechanisms of increased host susceptibility to secondary infections remain unknown. In humans, coronaviruses, including SARS-CoV-2, infect lung immune cells, including alveolar macrophages, a phenotype poorly replicated in mouse models of SARS-CoV-2. To overcome this, we used a mouse model of native murine β-coronavirus that infects both immune and structural cells to investigate coronavirus-enhanced susceptibility to bacterial infections. Our data show that coronavirus infection impairs the host ability to clear invading bacterial pathogens and potentiates lung tissue damage in mice. Mechanistically, coronavirus limits the bacterial killing ability of macrophages by impairing lysosomal acidification and fusion with engulfed bacteria. In addition, coronavirus-induced lysosomal dysfunction promotes pyroptotic cell death and the release of IL-1β. Inhibition of cathepsin B decreased cell death and IL-1β release and promoted bacterial clearance in mice with postcoronavirus bacterial infection.
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Registered trials
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